Wave-CAIPI enables highly accelerated 3D MRI

Berkin Bilgic, Stephen F. Cauley, Audrey P. Fan, Jonathan R. Polimeni, Lawrence L. Wald, Kawin Setsompop, Borjan A. Gagoski, P. Ellen Grant

Research output: Chapter in Book/Report/Conference proceedingConference contribution


We introduce Wave-CAIPI acquisition-reconstruction technique to accelerate 3D MR Imaging by an order of magnitude, with negligible noise amplification and image artifact penalties. Wave-CAIPI involves playing sinusoidal Gy and Gz gradients during the readout of each phase encoding line while modifying the phase encoding strategy to incur slice shifts as in 2D-CAIPI. This combination spreads out aliasing due to data undersampling evenly in all spatial directions, thereby taking full advantage of 3D coil sensitivity distribution of the receiver coil. By expressing the voxel spreading effect as a convolution in image space, an efficient reconstruction scheme that recovers the undersampled data without data gridding is proposed. Wave-CAIPI enables full-brain gradient echo (GRE) acquisition in 2.3 minutes with 1 mm isotropic voxel size and R=3×3 acceleration, and yields maximum g-factors (noise amplification) of 1.08 at 3T, and 1.05 at 7T. Relative to state of the art accelerated imaging methods, this is a factor of 2 reduction in maximum g-factor at 3T and 7T.

Original languageEnglish (US)
Title of host publicationProceedings - 2014 40th Annual Northeast Bioengineering Conference, NEBEC 2014
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781479937288
StatePublished - Dec 2 2014
Externally publishedYes
Event2014 40th Annual Northeast Bioengineering Conference, NEBEC 2014 - Boston, United States
Duration: Apr 25 2014Apr 27 2014

Publication series

NameProceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC
ISSN (Print)1071-121X
ISSN (Electronic)2160-7001


Conference2014 40th Annual Northeast Bioengineering Conference, NEBEC 2014
Country/TerritoryUnited States


  • Accelerated MRI
  • Image Reconstruction
  • Parallel Imaging

ASJC Scopus subject areas

  • Bioengineering


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