Voxel and surface-based topography of memory and executive deficits in mild cognitive impairment and Alzheimer's disease

Kwangsik Nho, Shannon L. Risacher, Paul K. Crane, Charles DeCarli, M. Maria Glymour, Christian Habeck, Sungeun Kim, Grace J. Lee, Elizabeth Mormino, Shubhabrata Mukherjee, Li Shen, John D. West, Andrew J. Saykin

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

Mild cognitive impairment (MCI) and Alzheimer's disease (AD) are associated with a progressive loss of cognitive abilities. In the present report, we assessed the relationship of memory and executive function with brain structure in a sample of 810 Alzheimer's Disease Neuroimaging Initiative (ADNI) participants, including 188 AD, 396 MCI, and 226 healthy older adults (HC). Composite scores of memory (ADNI-Mem) and executive function (ADNI-Exec) were generated by applying modern psychometric theory to item-level data from ADNI's neuropsychological battery. We performed voxel-based morphometry (VBM) and surface-based association (SurfStat) analyses to evaluate relationships of ADNI-Mem and ADNI-Exec with grey matter (GM) density and cortical thickness across the whole brain in the combined sample and within diagnostic groups. We observed strong associations between ADNI-Mem and medial and lateral temporal lobe atrophy. Lower ADNI-Exec scores were associated with advanced GM and cortical atrophy across broadly distributed regions, most impressively in the bilateral parietal and temporal lobes. We also evaluated ADNI-Exec adjusted for ADNI-Mem, and found associations with GM density and cortical thickness primarily in the bilateral parietal, temporal, and frontal lobes. Within-group analyses suggest these associations are strongest in patients with MCI and AD. The present study provides insight into the spatially unbiased associations between brain atrophy and memory and executive function, and underscores the importance of structural brain changes in early cognitive decline.

Original languageEnglish (US)
Pages (from-to)551-567
Number of pages17
JournalBrain Imaging and Behavior
Volume6
Issue number4
DOIs
StatePublished - 2012

Keywords

  • Alzheimer's disease
  • Executive function
  • Memory
  • Mild cognitive impairment
  • Surface-based analysis
  • Voxel-based morphometry (VBM)

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Neurology
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience
  • Behavioral Neuroscience
  • Radiology Nuclear Medicine and imaging

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    Nho, K., Risacher, S. L., Crane, P. K., DeCarli, C., Glymour, M. M., Habeck, C., Kim, S., Lee, G. J., Mormino, E., Mukherjee, S., Shen, L., West, J. D., & Saykin, A. J. (2012). Voxel and surface-based topography of memory and executive deficits in mild cognitive impairment and Alzheimer's disease. Brain Imaging and Behavior, 6(4), 551-567. https://doi.org/10.1007/s11682-012-9203-2