Abstract
Phase variance-based motion contrast imaging is demonstrated using a spectral domain optical coherence tomography system for the in vivo human retina. This contrast technique spatially identifies locations of motion within the retina primarily associated with vasculature. Histogrambased noise analysis of the motion contrast images was used to reduce the motion noise created by transverse eye motion. En face summation images created from the 3D motion contrast data are presented with segmentation of selected retinal layers to provide non-invasive vascular visualization comparable to currently used invasive angiographic imaging. This motion contrast technique has demonstrated the ability to visualize resolutionlimited vasculature independent of vessel orientation and flow velocity.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 22190-22200 |
| Number of pages | 11 |
| Journal | Optics Express |
| Volume | 17 |
| Issue number | 24 |
| DOIs | |
| State | Published - Nov 23 2009 |
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ASJC Scopus subject areas
- Atomic and Molecular Physics, and Optics
Cite this
Volumetric microvascular imaging of human retina using optical coherence tomography with a novel motion contrast technique. / Fingler, Jeff; Zawadzki, Robert; Werner, John S; Schwartz, Dan; Fraserl, Scott E.
In: Optics Express, Vol. 17, No. 24, 23.11.2009, p. 22190-22200.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Volumetric microvascular imaging of human retina using optical coherence tomography with a novel motion contrast technique
AU - Fingler, Jeff
AU - Zawadzki, Robert
AU - Werner, John S
AU - Schwartz, Dan
AU - Fraserl, Scott E.
PY - 2009/11/23
Y1 - 2009/11/23
N2 - Phase variance-based motion contrast imaging is demonstrated using a spectral domain optical coherence tomography system for the in vivo human retina. This contrast technique spatially identifies locations of motion within the retina primarily associated with vasculature. Histogrambased noise analysis of the motion contrast images was used to reduce the motion noise created by transverse eye motion. En face summation images created from the 3D motion contrast data are presented with segmentation of selected retinal layers to provide non-invasive vascular visualization comparable to currently used invasive angiographic imaging. This motion contrast technique has demonstrated the ability to visualize resolutionlimited vasculature independent of vessel orientation and flow velocity.
AB - Phase variance-based motion contrast imaging is demonstrated using a spectral domain optical coherence tomography system for the in vivo human retina. This contrast technique spatially identifies locations of motion within the retina primarily associated with vasculature. Histogrambased noise analysis of the motion contrast images was used to reduce the motion noise created by transverse eye motion. En face summation images created from the 3D motion contrast data are presented with segmentation of selected retinal layers to provide non-invasive vascular visualization comparable to currently used invasive angiographic imaging. This motion contrast technique has demonstrated the ability to visualize resolutionlimited vasculature independent of vessel orientation and flow velocity.
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UR - http://www.scopus.com/inward/citedby.url?scp=72449129943&partnerID=8YFLogxK
U2 - 10.1364/OE.17.022190
DO - 10.1364/OE.17.022190
M3 - Article
C2 - 19997465
AN - SCOPUS:72449129943
VL - 17
SP - 22190
EP - 22200
JO - Optics Express
JF - Optics Express
SN - 1094-4087
IS - 24
ER -