Volumetric microvascular imaging of human retina using optical coherence tomography with a novel motion contrast technique

Jeff Fingler, Robert Zawadzki, John S Werner, Dan Schwartz, Scott E. Fraserl

Research output: Contribution to journalArticle

145 Scopus citations

Abstract

Phase variance-based motion contrast imaging is demonstrated using a spectral domain optical coherence tomography system for the in vivo human retina. This contrast technique spatially identifies locations of motion within the retina primarily associated with vasculature. Histogrambased noise analysis of the motion contrast images was used to reduce the motion noise created by transverse eye motion. En face summation images created from the 3D motion contrast data are presented with segmentation of selected retinal layers to provide non-invasive vascular visualization comparable to currently used invasive angiographic imaging. This motion contrast technique has demonstrated the ability to visualize resolutionlimited vasculature independent of vessel orientation and flow velocity.

Original languageEnglish (US)
Pages (from-to)22190-22200
Number of pages11
JournalOptics Express
Volume17
Issue number24
DOIs
StatePublished - Nov 23 2009

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

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