Volumetric magnetic resonance imaging in patients with secondary generalized epilepsy

Craig Watson, Fernando Cendes, Frederick Andermann, Francois Dubeau, Bill Williamson, Alan Evans

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Magnetic resonance imaging (MRI)-based volumetric measurements of the hippocampus and amygdala (AM) are useful in detecting unilateral hippocampal and amygdaloid sclerosis in patients with temporal lobe epilepsy. In these pathologic entities, volumetric MRI analysis shows the epileptogenic structures to be atrophic as compared with the normal, nonepileptogenic side. Some researchers have suggested that the radiological features of atrophy of medial temporal lobe structures are common in patients with complex partial seizures but also are frequently observed in other seizure types and can occur even in patients without epilepsy. We prospectively studied 22 consecutive patients with secondary generalized epilepsy using volumetric MRI measurements of the AM and hippocampal formation (HF). AM and HF ratios (smaller side/larger side) were calculated to assess side-to-side asymmetry. Hippocampal and amygdaloid volumes and ratios were within the normal range in all our patients as compared with those of our normal control population. Significant reduction in hippocampal and amygdaloid volumes is a specific marker for hippocampal and amygdaloid sclerosis.

Original languageEnglish (US)
Pages (from-to)14-19
Number of pages6
JournalJournal of Epilepsy
Issue number1
StatePublished - 1996
Externally publishedYes


  • Amygdaloid sclerosis
  • Hippocampal sclerosis
  • Secondary generalized epilepsy
  • Volumetric magnetic resonance imaging

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)


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