Volumetric magnetic resonance imaging in patients with epilepsy and extratemporal structural lesions

Craig Watson, Bill Williamson

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

We studied 30 patients with epilepsy and extratemporal structural lesions using volumetric magnetic resonance imaging (MRI) measurements of the amygdala and hippocampus to determine if seizures originating in extratemporal sites caused cell loss and atrophy of medial temporal structures. Seizure types included simple partial seizures in 22 patients, complex partial in 12, secondarily generalized in 15, and drop attacks in 2. The location of the MRI lesions was in the frontal lobe in 19 patients, parietal lobe in 11, occipital lobe in 4, intraventricular in 1, and multifocal in 1. Lesions included tumors in 8 patients, developmental anomalies in 8, atrophic lesions in 6, vascular malformations in 4, and cystic, traumatic, gliotic, and ischemic lesions in 1 each. Hippocampal and amygdaloid volumes were within the normal range in all patients when compared to the normal control group. One patient exhibited a mild asymmetry of the two sides, but this was felt to be part of the larger process of her structural lesion. Significant reduction in hippocampal and amygdaloid volumes is a specific marker for hippocampal and amygdaloid sclerosis.

Original languageEnglish (US)
Pages (from-to)80-87
Number of pages8
JournalJournal of Epilepsy
Volume7
Issue number2
DOIs
StatePublished - 1994

Keywords

  • Amygdaloid sclerosis
  • Extratemporal lesional epilepsy
  • Hippocampal sclerosis
  • Volumetric magnetic resonance imaging

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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