Voltage-Gated Closed-Loop Control of Small-Molecule Release from Alumina-Coated Nanoporous Gold Thin Film Electrodes

Zidong Li, Ozge Polat, Erkin Seker

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Precise timing and dosing of potent small-molecule drugs carries significant potential for effective pharmaceutical management of disorders that exhibit time-varying therapeutic windows such as epilepsy. This study demonstrates the use of alumina-coated nanoporous gold (np-Au) thin film electrodes for iontophoretic release of fluorescein as a small-molecule drug surrogate with picogram dosing and a few seconds temporal resolution. A custom microfluidic platform is engineered to trigger molecular release from an integrated np-Au chip and monitor the resulting time-varying fluorescein concentration. Following a systematic study of the influence of applied voltage on loading capacity and release kinetics, a LabVIEW-based closed-loop control interface is employed to demonstrate voltage-gated fluorescein release with preprogrammed arbitrary concentrations waveforms.

Original languageEnglish (US)
Article number1801292
JournalAdvanced Functional Materials
Volume28
Issue number29
DOIs
StatePublished - Jul 18 2018

Fingerprint

Aluminum Oxide
Fluorescein
Gold
drugs
Alumina
aluminum oxides
epilepsy
gold
Thin films
Electrodes
Molecules
electrodes
Electric potential
electric potential
thin films
temporal resolution
Microfluidics
Pharmaceutical Preparations
Drug products
molecules

Keywords

  • closed-loop control
  • drug delivery
  • iontophoresis
  • microfluidics
  • nanoporous gold

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

Cite this

Voltage-Gated Closed-Loop Control of Small-Molecule Release from Alumina-Coated Nanoporous Gold Thin Film Electrodes. / Li, Zidong; Polat, Ozge; Seker, Erkin.

In: Advanced Functional Materials, Vol. 28, No. 29, 1801292, 18.07.2018.

Research output: Contribution to journalArticle

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