VKORC1-1639A allele influences warfarin maintenance dosage among Blacks receiving warfarin anticoagulation: A retrospective cohort study

Fatima Donia Mili, Tenecia Allen, Paula Weinstein Wadell, W. Craig Hooper, Christine De Staercke, Christopher J. Bean, Cathy Lally, Harland Austin, Nanette K. Wenger

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Aim: The study objectives were to investigate the association between selected CYP2C9 and VKORC1 single nucleotide polymorphisms with serious bleeding or thrombotic risk, and to estimate mean daily maintenance dose of warfarin and international normalized ratio measurements among Blacks receiving warfarin anticoagulation. Methods: We conducted a retrospective cohort study among 230 Black adults receiving warfarin for a minimum of three consecutive months with a confirmed date of first dosage. Results: A lower mean daily maintenance dosage of warfarin was required to maintain an international normalized ratio measurement within the therapeutic range among Blacks with the VKORC1-1639G>A variant alleles ([G/A vs G/G, p = 0.02], [A/A vs G/A, p = 0.008] and [A/A vs G/G, p = 0.001]). Conclusion: Data indicated that VKORC1-1639A variant allele influenced warfarin daily maintenance dosage among our small, likely admixed Black patient population.

Original languageEnglish (US)
Pages (from-to)15-26
Number of pages12
JournalFuture Cardiology
Volume14
Issue number1
DOIs
StatePublished - Jan 2018
Externally publishedYes

Keywords

  • antianticoagulation
  • Blacks
  • CYP2C9
  • Pharmacogenetics
  • Thromboembolism
  • VKORC1
  • VKORC1-1639GA warfarin

ASJC Scopus subject areas

  • Molecular Medicine
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'VKORC1-1639A allele influences warfarin maintenance dosage among Blacks receiving warfarin anticoagulation: A retrospective cohort study'. Together they form a unique fingerprint.

Cite this