Vitamin E deficiency and prostaglandin synthesis in rat testes

Patricia Willms, Prithiva Chanmugam, Daniel H. Hwang

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


A group of 8 weanling rats was fed a vitamin E(VE) deficient diet (D) and a control group was fed a VE sufficient diet (C) for 19 weeks. Levels of docosapentaenoic acid (22:5w6) in testis parenchyma lipids were significantly lower (p<0.05) in group D compared with group C. This decrease in 22:5w6, however, was not accompanied by the documented decrease in total testis weight of the VE deficient group. These results suggest that the 22:5w6 level in testis parenchyma lipids may be a sensitive indicator of VE deficiency in rats. There was no difference in the arachidonic acid (AA) level of testis parenchyma lipids between two groups. The tunica was the major site of prostaglandin (PG) synthesis in the testicular tissue and prostacyclin was the major PG synthesized from exogenous AA in the tunica. Both PGE2 and 6-keto-PGF derived from endogenous AA in tunica homogenate affer 30 min incubation appear to be greater in the control group than in the deficient group, although the difference was not statistically significant. These results imply that increased lipid peroxidation in VE deficiency can result in greater inactivation of PGH synthetase and thus can reduce the synthesis of PGs during the incubation.

Original languageEnglish (US)
Pages (from-to)273-284
Number of pages12
JournalNutrition Research
Issue number3
StatePublished - 1987
Externally publishedYes


  • Prostaglandins
  • Rat Testis
  • Vitamin E

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics


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