TY - JOUR
T1 - Vitamin D status and rates of cognitive decline in a multiethnic cohort of older adults
AU - Miller, Joshua W.
AU - Harvey, Danielle J
AU - Beckett, Laurel A
AU - Green, Ralph
AU - Tomaszewski Farias, Sarah E
AU - Reed, Bruce R
AU - Olichney, John M
AU - Mungas, Dan M
AU - DeCarli, Charles
PY - 2015/11/1
Y1 - 2015/11/1
N2 - IMPORTANCE: Vitamin D (VitD) deficiency is associated with brain structural abnormalities, cognitive decline, and incident dementia. OBJECTIVE: To assess associations between VitD status and trajectories of change in subdomains of cognitive function in a cohort of ethnically diverse older adults. DESIGN, SETTING, AND PARTICIPANTS: Longitudinal multiethnic cohort study of 382 participants in an outpatient clinic enrolled between February 2002 and August 2010 with baseline assessment and yearly follow-up visits. Serum 25-hydroxyvitamin D (25-OHD) was measured, with VitD status defined as the following: deficient, less than 12 ng/mL (to convert to nanomoles per liter, multiply by 2.496); insufficient, 12 to less than 20 ng/mL; adequate, 20 to less than 50 ng/mL; or high, 50 ng/mL or higher. Subdomains of cognitive function were assessed using the Spanish and English Neuropsychological Assessment Scales. Associations were evaluated between 25-OHD levels (as continuous and categorical [deficient, insufficient, or adequate]) and trajectories of cognitive decline. MAIN OUTCOMES AND MEASURES: Serum 25-OHD levels, cognitive function, and associations between 25-OHD levels and trajectories of cognitive decline. RESULTS: Participants (N = 382 at baseline) had a mean (SD) age of 75.5 (7.0) years; 61.8% were women; and 41.4%were white, 29.6%African American, 25.1%Hispanic, and 3.9% other race/ethnicity. Diagnosis at enrollment included 17.5%with dementia, 32.7%with mild cognitive impairment, and 49.5%cognitively normal. The mean (SD) 25-OHD level was 19.2 (11.7) ng/mL, with 26.2%of participants being VitD deficient and 35.1%insufficient. The mean (SD) 25-OHD levels were significantly lower for African American and Hispanic participants compared with white participants (17.9 [15.8] and 17.2 [8.4] vs 21.7 [10.0] ng/mL, respectively; P
AB - IMPORTANCE: Vitamin D (VitD) deficiency is associated with brain structural abnormalities, cognitive decline, and incident dementia. OBJECTIVE: To assess associations between VitD status and trajectories of change in subdomains of cognitive function in a cohort of ethnically diverse older adults. DESIGN, SETTING, AND PARTICIPANTS: Longitudinal multiethnic cohort study of 382 participants in an outpatient clinic enrolled between February 2002 and August 2010 with baseline assessment and yearly follow-up visits. Serum 25-hydroxyvitamin D (25-OHD) was measured, with VitD status defined as the following: deficient, less than 12 ng/mL (to convert to nanomoles per liter, multiply by 2.496); insufficient, 12 to less than 20 ng/mL; adequate, 20 to less than 50 ng/mL; or high, 50 ng/mL or higher. Subdomains of cognitive function were assessed using the Spanish and English Neuropsychological Assessment Scales. Associations were evaluated between 25-OHD levels (as continuous and categorical [deficient, insufficient, or adequate]) and trajectories of cognitive decline. MAIN OUTCOMES AND MEASURES: Serum 25-OHD levels, cognitive function, and associations between 25-OHD levels and trajectories of cognitive decline. RESULTS: Participants (N = 382 at baseline) had a mean (SD) age of 75.5 (7.0) years; 61.8% were women; and 41.4%were white, 29.6%African American, 25.1%Hispanic, and 3.9% other race/ethnicity. Diagnosis at enrollment included 17.5%with dementia, 32.7%with mild cognitive impairment, and 49.5%cognitively normal. The mean (SD) 25-OHD level was 19.2 (11.7) ng/mL, with 26.2%of participants being VitD deficient and 35.1%insufficient. The mean (SD) 25-OHD levels were significantly lower for African American and Hispanic participants compared with white participants (17.9 [15.8] and 17.2 [8.4] vs 21.7 [10.0] ng/mL, respectively; P
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U2 - 10.1001/jamaneurol.2015.2115
DO - 10.1001/jamaneurol.2015.2115
M3 - Article
C2 - 26366714
AN - SCOPUS:84946075438
VL - 72
SP - 1295
EP - 1303
JO - JAMA Neurology
JF - JAMA Neurology
SN - 2168-6149
IS - 11
ER -