Vitamin D receptor Fok1 polymorphisms affect calcium absorption, kinetics, and bone mineralization rates during puberty

Steven A. Abrams, Ian J. Griffin, Keli M. Hawthorne, Zhensheng Chen, Sheila K. Gunn, Margaret Wilde, Gretchen Darlington, Roman J. Shypailo, Kenneth J. Ellis

Research output: Contribution to journalArticle

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Abstract

Few studies of the VDR polymorphisms have looked at calcium metabolism or long-term effects. We measured bone mineralization and calcium metabolic parameters longitudinally in a group of 99 adolescents. We found a significant relationship between calcium absorption and skeletal calcium accretion and the Fok1, but not other VDR or related, genetic polymorphisms. It seems that the Fok1 polymorphism directly affects bone mineralization during pubertal growth through an effect on calcium absorption. Introduction: There are few data regarding the relationship between genetic markers for low bone mass and changes in calcium metabolism in childhood or adolescence. We sought to identify the effects of polymorphisms of the vitamin D receptor (VDR) on calcium and bone mineral metabolism in a longitudinal study of pubertal adolescents. Materials and Methods: Adolescents (n = 99) received comprehensive stable isotope studies of calcium absorption, bone calcium kinetics, and bone mineralization. Studies were repeated 12 months later. Polymorphisms of putative genetic markers were determined and related to bone mineralization and calcium metabolic finding. Results were analyzed by ANOVA in which changes over time were determined using the initial value as a covariate. Results: Polymorphisms of the Fok1 gene of the VDR were significantly related to calcium absorption (p = 0.008) and whole body BMC (p = 0.03) and BMD (p = 0.006). The Fok1 effect on whole body BMD was significant for those with Ca intake >800 mg/day (p < 0.001), whereas for those with Ca intake ≤800 mg/day, the Fok1 genotype did not have a significant effect on whole body BMD (p = 0.40). The Fok1 genotype was significantly related to the changes during the year in whole body calcium accretion, with the ff genotype having a 63 ± 20 mg/day deficit compared with the FF genotype (p = 0.008). Conclusions: The Fok1 polymorphism of the VDR receptor seems to directly affect bone mineral accretion during pubertal growth through an effect on calcium absorption. The relationship between different genetic polymorphisms and bone mineral metabolism may vary by life stage as well as diet.

Original languageEnglish (US)
Pages (from-to)945-953
Number of pages9
JournalJournal of Bone and Mineral Research
Volume20
Issue number6
DOIs
StatePublished - Jun 2005
Externally publishedYes

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Physiologic Calcification
Calcitriol Receptors
Puberty
Calcium
Bone and Bones
Genotype
Minerals
Genetic Polymorphisms
Genetic Markers
Calcium Isotopes
Growth
Longitudinal Studies
Analysis of Variance

Keywords

  • Bone mineralization
  • Calcium absorption
  • Calcium kinetics
  • Stable isotopes
  • Vitamin D receptor

ASJC Scopus subject areas

  • Surgery

Cite this

Abrams, S. A., Griffin, I. J., Hawthorne, K. M., Chen, Z., Gunn, S. K., Wilde, M., ... Ellis, K. J. (2005). Vitamin D receptor Fok1 polymorphisms affect calcium absorption, kinetics, and bone mineralization rates during puberty. Journal of Bone and Mineral Research, 20(6), 945-953. https://doi.org/10.1359/JBMR.050114

Vitamin D receptor Fok1 polymorphisms affect calcium absorption, kinetics, and bone mineralization rates during puberty. / Abrams, Steven A.; Griffin, Ian J.; Hawthorne, Keli M.; Chen, Zhensheng; Gunn, Sheila K.; Wilde, Margaret; Darlington, Gretchen; Shypailo, Roman J.; Ellis, Kenneth J.

In: Journal of Bone and Mineral Research, Vol. 20, No. 6, 06.2005, p. 945-953.

Research output: Contribution to journalArticle

Abrams, SA, Griffin, IJ, Hawthorne, KM, Chen, Z, Gunn, SK, Wilde, M, Darlington, G, Shypailo, RJ & Ellis, KJ 2005, 'Vitamin D receptor Fok1 polymorphisms affect calcium absorption, kinetics, and bone mineralization rates during puberty', Journal of Bone and Mineral Research, vol. 20, no. 6, pp. 945-953. https://doi.org/10.1359/JBMR.050114
Abrams, Steven A. ; Griffin, Ian J. ; Hawthorne, Keli M. ; Chen, Zhensheng ; Gunn, Sheila K. ; Wilde, Margaret ; Darlington, Gretchen ; Shypailo, Roman J. ; Ellis, Kenneth J. / Vitamin D receptor Fok1 polymorphisms affect calcium absorption, kinetics, and bone mineralization rates during puberty. In: Journal of Bone and Mineral Research. 2005 ; Vol. 20, No. 6. pp. 945-953.
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abstract = "Few studies of the VDR polymorphisms have looked at calcium metabolism or long-term effects. We measured bone mineralization and calcium metabolic parameters longitudinally in a group of 99 adolescents. We found a significant relationship between calcium absorption and skeletal calcium accretion and the Fok1, but not other VDR or related, genetic polymorphisms. It seems that the Fok1 polymorphism directly affects bone mineralization during pubertal growth through an effect on calcium absorption. Introduction: There are few data regarding the relationship between genetic markers for low bone mass and changes in calcium metabolism in childhood or adolescence. We sought to identify the effects of polymorphisms of the vitamin D receptor (VDR) on calcium and bone mineral metabolism in a longitudinal study of pubertal adolescents. Materials and Methods: Adolescents (n = 99) received comprehensive stable isotope studies of calcium absorption, bone calcium kinetics, and bone mineralization. Studies were repeated 12 months later. Polymorphisms of putative genetic markers were determined and related to bone mineralization and calcium metabolic finding. Results were analyzed by ANOVA in which changes over time were determined using the initial value as a covariate. Results: Polymorphisms of the Fok1 gene of the VDR were significantly related to calcium absorption (p = 0.008) and whole body BMC (p = 0.03) and BMD (p = 0.006). The Fok1 effect on whole body BMD was significant for those with Ca intake >800 mg/day (p < 0.001), whereas for those with Ca intake ≤800 mg/day, the Fok1 genotype did not have a significant effect on whole body BMD (p = 0.40). The Fok1 genotype was significantly related to the changes during the year in whole body calcium accretion, with the ff genotype having a 63 ± 20 mg/day deficit compared with the FF genotype (p = 0.008). Conclusions: The Fok1 polymorphism of the VDR receptor seems to directly affect bone mineral accretion during pubertal growth through an effect on calcium absorption. The relationship between different genetic polymorphisms and bone mineral metabolism may vary by life stage as well as diet.",
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AU - Griffin, Ian J.

AU - Hawthorne, Keli M.

AU - Chen, Zhensheng

AU - Gunn, Sheila K.

AU - Wilde, Margaret

AU - Darlington, Gretchen

AU - Shypailo, Roman J.

AU - Ellis, Kenneth J.

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AB - Few studies of the VDR polymorphisms have looked at calcium metabolism or long-term effects. We measured bone mineralization and calcium metabolic parameters longitudinally in a group of 99 adolescents. We found a significant relationship between calcium absorption and skeletal calcium accretion and the Fok1, but not other VDR or related, genetic polymorphisms. It seems that the Fok1 polymorphism directly affects bone mineralization during pubertal growth through an effect on calcium absorption. Introduction: There are few data regarding the relationship between genetic markers for low bone mass and changes in calcium metabolism in childhood or adolescence. We sought to identify the effects of polymorphisms of the vitamin D receptor (VDR) on calcium and bone mineral metabolism in a longitudinal study of pubertal adolescents. Materials and Methods: Adolescents (n = 99) received comprehensive stable isotope studies of calcium absorption, bone calcium kinetics, and bone mineralization. Studies were repeated 12 months later. Polymorphisms of putative genetic markers were determined and related to bone mineralization and calcium metabolic finding. Results were analyzed by ANOVA in which changes over time were determined using the initial value as a covariate. Results: Polymorphisms of the Fok1 gene of the VDR were significantly related to calcium absorption (p = 0.008) and whole body BMC (p = 0.03) and BMD (p = 0.006). The Fok1 effect on whole body BMD was significant for those with Ca intake >800 mg/day (p < 0.001), whereas for those with Ca intake ≤800 mg/day, the Fok1 genotype did not have a significant effect on whole body BMD (p = 0.40). The Fok1 genotype was significantly related to the changes during the year in whole body calcium accretion, with the ff genotype having a 63 ± 20 mg/day deficit compared with the FF genotype (p = 0.008). Conclusions: The Fok1 polymorphism of the VDR receptor seems to directly affect bone mineral accretion during pubertal growth through an effect on calcium absorption. The relationship between different genetic polymorphisms and bone mineral metabolism may vary by life stage as well as diet.

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KW - Calcium absorption

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