Abstract
Vitamin D deficiency has been linked with increased cancer risk, and vitamin D has been shown to be cytotoxic to some cancer cells in vitro. In the present study we evaluated whether vitamin D would have antiproliferative or cytotoxic effects on human pre-B acute lymphoblastic leukemia cells. Contrary to our hypotheses, calcitriol, the active form of vitamin D, had no effect on leukemia cell proliferation. Calcitriol actually had a modest effect to impair dexamethasone cytotoxicity and induction of apoptosis. Further studies are needed to evaluate the effects of vitamin D on leukemia cells in vivo.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 591-593 |
| Number of pages | 3 |
| Journal | Leukemia Research |
| Volume | 36 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 1 2012 |
| Externally published | Yes |
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Keywords
- Acute lymphoblastic leukemia
- Calcitriol
- Dexamethasone
- Vitamin D
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research
Cite this
Vitamin D protects acute lymphoblastic leukemia cells from dexamethasone. / Antony, Reuben; Sheng, Xia; Ehsanipour, Ehsan A.; Ng, Emily; Pramanik, Rocky; Klemm, Lars; Ichihara, Brian; Mittelman, Steven D.
In: Leukemia Research, Vol. 36, No. 5, 01.05.2012, p. 591-593.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Vitamin D protects acute lymphoblastic leukemia cells from dexamethasone
AU - Antony, Reuben
AU - Sheng, Xia
AU - Ehsanipour, Ehsan A.
AU - Ng, Emily
AU - Pramanik, Rocky
AU - Klemm, Lars
AU - Ichihara, Brian
AU - Mittelman, Steven D.
PY - 2012/5/1
Y1 - 2012/5/1
N2 - Vitamin D deficiency has been linked with increased cancer risk, and vitamin D has been shown to be cytotoxic to some cancer cells in vitro. In the present study we evaluated whether vitamin D would have antiproliferative or cytotoxic effects on human pre-B acute lymphoblastic leukemia cells. Contrary to our hypotheses, calcitriol, the active form of vitamin D, had no effect on leukemia cell proliferation. Calcitriol actually had a modest effect to impair dexamethasone cytotoxicity and induction of apoptosis. Further studies are needed to evaluate the effects of vitamin D on leukemia cells in vivo.
AB - Vitamin D deficiency has been linked with increased cancer risk, and vitamin D has been shown to be cytotoxic to some cancer cells in vitro. In the present study we evaluated whether vitamin D would have antiproliferative or cytotoxic effects on human pre-B acute lymphoblastic leukemia cells. Contrary to our hypotheses, calcitriol, the active form of vitamin D, had no effect on leukemia cell proliferation. Calcitriol actually had a modest effect to impair dexamethasone cytotoxicity and induction of apoptosis. Further studies are needed to evaluate the effects of vitamin D on leukemia cells in vivo.
KW - Acute lymphoblastic leukemia
KW - Calcitriol
KW - Dexamethasone
KW - Vitamin D
UR - http://www.scopus.com/inward/record.url?scp=84858746221&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84858746221&partnerID=8YFLogxK
U2 - 10.1016/j.leukres.2012.01.011
DO - 10.1016/j.leukres.2012.01.011
M3 - Article
VL - 36
SP - 591
EP - 593
JO - Leukemia Research
JF - Leukemia Research
SN - 0145-2126
IS - 5
ER -