Abstract
Vitamin D deficiency has been linked with increased cancer risk, and vitamin D has been shown to be cytotoxic to some cancer cells in vitro. In the present study we evaluated whether vitamin D would have antiproliferative or cytotoxic effects on human pre-B acute lymphoblastic leukemia cells. Contrary to our hypotheses, calcitriol, the active form of vitamin D, had no effect on leukemia cell proliferation. Calcitriol actually had a modest effect to impair dexamethasone cytotoxicity and induction of apoptosis. Further studies are needed to evaluate the effects of vitamin D on leukemia cells in vivo.
Original language | English (US) |
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Pages (from-to) | 591-593 |
Number of pages | 3 |
Journal | Leukemia Research |
Volume | 36 |
Issue number | 5 |
DOIs | |
State | Published - May 1 2012 |
Externally published | Yes |
Keywords
- Acute lymphoblastic leukemia
- Calcitriol
- Dexamethasone
- Vitamin D
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research