Vitamin D protects acute lymphoblastic leukemia cells from dexamethasone

Reuben Antony, Xia Sheng, Ehsan A. Ehsanipour, Emily Ng, Rocky Pramanik, Lars Klemm, Brian Ichihara, Steven D. Mittelman

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Vitamin D deficiency has been linked with increased cancer risk, and vitamin D has been shown to be cytotoxic to some cancer cells in vitro. In the present study we evaluated whether vitamin D would have antiproliferative or cytotoxic effects on human pre-B acute lymphoblastic leukemia cells. Contrary to our hypotheses, calcitriol, the active form of vitamin D, had no effect on leukemia cell proliferation. Calcitriol actually had a modest effect to impair dexamethasone cytotoxicity and induction of apoptosis. Further studies are needed to evaluate the effects of vitamin D on leukemia cells in vivo.

Original languageEnglish (US)
Pages (from-to)591-593
Number of pages3
JournalLeukemia Research
Volume36
Issue number5
DOIs
StatePublished - May 1 2012
Externally publishedYes

Fingerprint

Precursor Cell Lymphoblastic Leukemia-Lymphoma
Vitamin D
Dexamethasone
Calcitriol
Leukemia
Vitamin D Deficiency
Neoplasms
Cell Proliferation
Apoptosis

Keywords

  • Acute lymphoblastic leukemia
  • Calcitriol
  • Dexamethasone
  • Vitamin D

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

Antony, R., Sheng, X., Ehsanipour, E. A., Ng, E., Pramanik, R., Klemm, L., ... Mittelman, S. D. (2012). Vitamin D protects acute lymphoblastic leukemia cells from dexamethasone. Leukemia Research, 36(5), 591-593. https://doi.org/10.1016/j.leukres.2012.01.011

Vitamin D protects acute lymphoblastic leukemia cells from dexamethasone. / Antony, Reuben; Sheng, Xia; Ehsanipour, Ehsan A.; Ng, Emily; Pramanik, Rocky; Klemm, Lars; Ichihara, Brian; Mittelman, Steven D.

In: Leukemia Research, Vol. 36, No. 5, 01.05.2012, p. 591-593.

Research output: Contribution to journalArticle

Antony, R, Sheng, X, Ehsanipour, EA, Ng, E, Pramanik, R, Klemm, L, Ichihara, B & Mittelman, SD 2012, 'Vitamin D protects acute lymphoblastic leukemia cells from dexamethasone', Leukemia Research, vol. 36, no. 5, pp. 591-593. https://doi.org/10.1016/j.leukres.2012.01.011
Antony, Reuben ; Sheng, Xia ; Ehsanipour, Ehsan A. ; Ng, Emily ; Pramanik, Rocky ; Klemm, Lars ; Ichihara, Brian ; Mittelman, Steven D. / Vitamin D protects acute lymphoblastic leukemia cells from dexamethasone. In: Leukemia Research. 2012 ; Vol. 36, No. 5. pp. 591-593.
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