Vitamin D protects acute lymphoblastic leukemia cells from dexamethasone

Reuben Antony, Xia Sheng, Ehsan A. Ehsanipour, Emily Ng, Rocky Pramanik, Lars Klemm, Brian Ichihara, Steven D. Mittelman

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Vitamin D deficiency has been linked with increased cancer risk, and vitamin D has been shown to be cytotoxic to some cancer cells in vitro. In the present study we evaluated whether vitamin D would have antiproliferative or cytotoxic effects on human pre-B acute lymphoblastic leukemia cells. Contrary to our hypotheses, calcitriol, the active form of vitamin D, had no effect on leukemia cell proliferation. Calcitriol actually had a modest effect to impair dexamethasone cytotoxicity and induction of apoptosis. Further studies are needed to evaluate the effects of vitamin D on leukemia cells in vivo.

Original languageEnglish (US)
Pages (from-to)591-593
Number of pages3
JournalLeukemia Research
Volume36
Issue number5
DOIs
StatePublished - May 1 2012
Externally publishedYes

Keywords

  • Acute lymphoblastic leukemia
  • Calcitriol
  • Dexamethasone
  • Vitamin D

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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