Abstract
Vitamin D deficiency has been linked with increased cancer risk, and vitamin D has been shown to be cytotoxic to some cancer cells in vitro. In the present study we evaluated whether vitamin D would have antiproliferative or cytotoxic effects on human pre-B acute lymphoblastic leukemia cells. Contrary to our hypotheses, calcitriol, the active form of vitamin D, had no effect on leukemia cell proliferation. Calcitriol actually had a modest effect to impair dexamethasone cytotoxicity and induction of apoptosis. Further studies are needed to evaluate the effects of vitamin D on leukemia cells in vivo.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 591-593 |
| Number of pages | 3 |
| Journal | Leukemia Research |
| Volume | 36 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 1 2012 |
| Externally published | Yes |
Keywords
- Acute lymphoblastic leukemia
- Calcitriol
- Dexamethasone
- Vitamin D
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research
Fingerprint Dive into the research topics of 'Vitamin D protects acute lymphoblastic leukemia cells from dexamethasone'. Together they form a unique fingerprint.
Cite this
Antony, R., Sheng, X., Ehsanipour, E. A., Ng, E., Pramanik, R., Klemm, L., Ichihara, B., & Mittelman, S. D. (2012). Vitamin D protects acute lymphoblastic leukemia cells from dexamethasone. Leukemia Research, 36(5), 591-593. https://doi.org/10.1016/j.leukres.2012.01.011