Vitamin D in primary biliary cirrhosis, a plausible marker of advanced disease

Nancy Agmon-Levin, Ron Kopilov, Carlo Selmi, Udi Nussinovitch, María Sánchez-Castañón, Marcos López-Hoyos, Howie Amital, Shaye Kivity, M. Eric Gershwin, Yehuda Shoenfeld

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Vitamin D immune-modulating effects were extensively studied, and low levels have been linked with autoimmune diseases. The associations of vitamin D with autoimmune diseases of the liver, and particularly primary biliary cirrhosis (PBC), are yet to be defined. Hence, in this study, serum levels of vitamin D were determined in 79 patients with PBC and 70 age- and sex-matched controls by the LIAISON chemiluminescent immunoassays (DiaSorin—Italy). Clinical and serological parameters of patients were analyzed with respect to vitamin D status. Mean levels of vitamin D were significantly lower among patients with PBC compared with controls (16.8 ± 9 vs. 22.1 ± 9 ng/ml; p = 0.029), and vitamin D deficiency (≤10 ng/ml) was documented in 33 % of patients with PBC versus 7 % of controls (p < 0.0001). Vitamin D levels inversely correlated with advanced liver damage and the presence of concomitant autoimmune diseases. In contrast, higher levels of vitamin D were observed among patients with PBC treated with ursodeoxycholic acid (UDCA). In conclusion, low vitamin D levels are common among patients with PBC and correlate with advanced disease, lack of UDCA therapy and autoimmune comorbidity. This alludes to the plausible roles of vitamin D as a prognostic marker of PBC severity, and as a potential player in this disease pathogenesis. While further studies are awaited, monitoring vitamin D in patients with PBC and use of supplements may be advisable.

Original languageEnglish (US)
Pages (from-to)141-146
Number of pages6
JournalImmunologic Research
Volume61
Issue number1-2
DOIs
StatePublished - 2014

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Biliary Liver Cirrhosis
Vitamin D
Autoimmune Diseases
Ursodeoxycholic Acid
Vitamin D Deficiency
Liver
Immunoassay
Comorbidity

Keywords

  • Autoantibodies
  • Autoimmunity
  • Liver
  • PBC (primary biliary cirrhosis)
  • Vitamin D

ASJC Scopus subject areas

  • Immunology

Cite this

Agmon-Levin, N., Kopilov, R., Selmi, C., Nussinovitch, U., Sánchez-Castañón, M., López-Hoyos, M., ... Shoenfeld, Y. (2014). Vitamin D in primary biliary cirrhosis, a plausible marker of advanced disease. Immunologic Research, 61(1-2), 141-146. https://doi.org/10.1007/s12026-014-8594-0

Vitamin D in primary biliary cirrhosis, a plausible marker of advanced disease. / Agmon-Levin, Nancy; Kopilov, Ron; Selmi, Carlo; Nussinovitch, Udi; Sánchez-Castañón, María; López-Hoyos, Marcos; Amital, Howie; Kivity, Shaye; Gershwin, M. Eric; Shoenfeld, Yehuda.

In: Immunologic Research, Vol. 61, No. 1-2, 2014, p. 141-146.

Research output: Contribution to journalArticle

Agmon-Levin, N, Kopilov, R, Selmi, C, Nussinovitch, U, Sánchez-Castañón, M, López-Hoyos, M, Amital, H, Kivity, S, Gershwin, ME & Shoenfeld, Y 2014, 'Vitamin D in primary biliary cirrhosis, a plausible marker of advanced disease', Immunologic Research, vol. 61, no. 1-2, pp. 141-146. https://doi.org/10.1007/s12026-014-8594-0
Agmon-Levin N, Kopilov R, Selmi C, Nussinovitch U, Sánchez-Castañón M, López-Hoyos M et al. Vitamin D in primary biliary cirrhosis, a plausible marker of advanced disease. Immunologic Research. 2014;61(1-2):141-146. https://doi.org/10.1007/s12026-014-8594-0
Agmon-Levin, Nancy ; Kopilov, Ron ; Selmi, Carlo ; Nussinovitch, Udi ; Sánchez-Castañón, María ; López-Hoyos, Marcos ; Amital, Howie ; Kivity, Shaye ; Gershwin, M. Eric ; Shoenfeld, Yehuda. / Vitamin D in primary biliary cirrhosis, a plausible marker of advanced disease. In: Immunologic Research. 2014 ; Vol. 61, No. 1-2. pp. 141-146.
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