Vitamin D Deficiency in Pregnant Ukrainian Women: Effects of Alcohol Consumption on Vitamin D Status

Charles R. Carlson, Janet Y. Uriu-Adams, Christina D. Chambers, Lyubov Yevtushok, Natalya Zymak-Zakutnya, Priscilla H. Chan, Jordan J. Schafer, Wladimir Wertelecki, Carl L Keen

Research output: Contribution to journalArticle

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Abstract

Objective: Heavy alcohol consumption can alter vitamin D status; however, the relationships between alcohol consumption and vitamin D concentrations in pregnant women have not been well studied. The aim of this study was to investigate the vitamin D status in a population of alcohol-exposed (N = 180) and low/unexposed control (N = 179) Ukrainian pregnant women. Methods: Women who attended prenatal care facilities in 2 regions of Ukraine (Rivne and Khmelnytsky) for a routine prenatal visit were screened for the study. At the time of enrollment (20.4 ± 7.0 weeks of gestation), blood samples and alcohol consumption data (during a typical week around conception and the most recent 2 weeks) were collected. Vitamin D status was assessed by 25-hydroxyvitamin D [25(OH)D] concentrations. Results: A high prevalence of suboptimal vitamin D status in pregnant Ukrainian women was observed. Overall, 50.1% and 33.4% of the women were classified as vitamin D deficient [25(OH)D < 20 ng/mL] or insufficient [25(OH)D ≥ 20 ng/mL and ≤30 ng/mL], respectively, based on 2011 Endocrine Society guidelines. Alcohol-exposed women had significantly lower 25(OH)D concentrations than low/unexposed women in Spring (p = 0.006) and Winter (p = 0.022). When vitamin D concentrations were grouped into sunny season (Summer + Fall) compared to not sunny season (Winter + Spring), there was a significant ethanol by season interaction (p = 0.0028), with alcohol-drinking women having lower circulating vitamin D compared to low/unexposed women in seasons of low sun availability. Conclusions: These data suggest that when vitamin D concentrations are generally low (e.g., during seasons of low sun availability), alcohol consumption during pregnancy has a negative impact on vitamin D status.

Original languageEnglish (US)
Pages (from-to)44-56
Number of pages13
JournalJournal of the American College of Nutrition
Volume36
Issue number1
DOIs
StatePublished - Jan 2 2017

Fingerprint

Vitamin D Deficiency
Vitamin D
Alcohol Drinking
Pregnant Women
Solar System
Alcohols
Ukraine
Pregnancy
Prenatal Care
Ethanol
Guidelines

Keywords

  • 25(OH)D
  • alcohol
  • pregnancy
  • vitamin D
  • vitamin D deficiency

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Carlson, C. R., Uriu-Adams, J. Y., Chambers, C. D., Yevtushok, L., Zymak-Zakutnya, N., Chan, P. H., ... Keen, C. L. (2017). Vitamin D Deficiency in Pregnant Ukrainian Women: Effects of Alcohol Consumption on Vitamin D Status. Journal of the American College of Nutrition, 36(1), 44-56. https://doi.org/10.1080/07315724.2016.1174091

Vitamin D Deficiency in Pregnant Ukrainian Women : Effects of Alcohol Consumption on Vitamin D Status. / Carlson, Charles R.; Uriu-Adams, Janet Y.; Chambers, Christina D.; Yevtushok, Lyubov; Zymak-Zakutnya, Natalya; Chan, Priscilla H.; Schafer, Jordan J.; Wertelecki, Wladimir; Keen, Carl L.

In: Journal of the American College of Nutrition, Vol. 36, No. 1, 02.01.2017, p. 44-56.

Research output: Contribution to journalArticle

Carlson, CR, Uriu-Adams, JY, Chambers, CD, Yevtushok, L, Zymak-Zakutnya, N, Chan, PH, Schafer, JJ, Wertelecki, W & Keen, CL 2017, 'Vitamin D Deficiency in Pregnant Ukrainian Women: Effects of Alcohol Consumption on Vitamin D Status', Journal of the American College of Nutrition, vol. 36, no. 1, pp. 44-56. https://doi.org/10.1080/07315724.2016.1174091
Carlson, Charles R. ; Uriu-Adams, Janet Y. ; Chambers, Christina D. ; Yevtushok, Lyubov ; Zymak-Zakutnya, Natalya ; Chan, Priscilla H. ; Schafer, Jordan J. ; Wertelecki, Wladimir ; Keen, Carl L. / Vitamin D Deficiency in Pregnant Ukrainian Women : Effects of Alcohol Consumption on Vitamin D Status. In: Journal of the American College of Nutrition. 2017 ; Vol. 36, No. 1. pp. 44-56.
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abstract = "Objective: Heavy alcohol consumption can alter vitamin D status; however, the relationships between alcohol consumption and vitamin D concentrations in pregnant women have not been well studied. The aim of this study was to investigate the vitamin D status in a population of alcohol-exposed (N = 180) and low/unexposed control (N = 179) Ukrainian pregnant women. Methods: Women who attended prenatal care facilities in 2 regions of Ukraine (Rivne and Khmelnytsky) for a routine prenatal visit were screened for the study. At the time of enrollment (20.4 ± 7.0 weeks of gestation), blood samples and alcohol consumption data (during a typical week around conception and the most recent 2 weeks) were collected. Vitamin D status was assessed by 25-hydroxyvitamin D [25(OH)D] concentrations. Results: A high prevalence of suboptimal vitamin D status in pregnant Ukrainian women was observed. Overall, 50.1{\%} and 33.4{\%} of the women were classified as vitamin D deficient [25(OH)D < 20 ng/mL] or insufficient [25(OH)D ≥ 20 ng/mL and ≤30 ng/mL], respectively, based on 2011 Endocrine Society guidelines. Alcohol-exposed women had significantly lower 25(OH)D concentrations than low/unexposed women in Spring (p = 0.006) and Winter (p = 0.022). When vitamin D concentrations were grouped into sunny season (Summer + Fall) compared to not sunny season (Winter + Spring), there was a significant ethanol by season interaction (p = 0.0028), with alcohol-drinking women having lower circulating vitamin D compared to low/unexposed women in seasons of low sun availability. Conclusions: These data suggest that when vitamin D concentrations are generally low (e.g., during seasons of low sun availability), alcohol consumption during pregnancy has a negative impact on vitamin D status.",
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AU - Zymak-Zakutnya, Natalya

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