Vitamin d and reproduction: From gametes to childhood

Krista D. Sowell, Carl L. Keen, Janet Y. Uriu-Adams

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


Vitamin D is well recognized for its essentiality in maintaining skeletal health. Recent research has suggested that vitamin D may exert a broad range of roles throughout the human life cycle starting from reproduction to adult chronic disease risk. Rates of vitamin D deficiency during pregnancy remain high worldwide. Vitamin D deficiency has been associated with an increased risk of fertility problems, preeclampsia, gestational diabetes, and allergic disease in the offspring. Vitamin D is found naturally in only a few foods thus supplementation can provide an accessible and effective way to raise vitamin D status when dietary intakes and sunlight exposure are low. However, the possibility of overconsumption and possible adverse effects is under debate. The effect of vitamin D supplementation during pregnancy and early life on maternal and infant outcomes will be of particular focus in this review.

Original languageEnglish (US)
Pages (from-to)1097-1120
Number of pages24
JournalHealthcare (Switzerland)
Issue number4
StatePublished - Dec 2015
Externally publishedYes


  • Allergic disease
  • Fertility
  • Gestational diabetes
  • Preeclampsia
  • Pregnancy
  • Toxicity
  • Vitamin D
  • Vitamin D supplementation

ASJC Scopus subject areas

  • Health Informatics
  • Health Policy
  • Health Information Management
  • Leadership and Management


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