Vitamin D and Albuminuria in Youth with and without Type 1 Diabetes

Debika Nandi-Munshi, Maryam Afkarian, Kathryn B. Whitlock, Jamie L. Crandell, Ronny A. Bell, Ralph D'Agostino, Sharon Saydah, Amy K. Mottl, Dana Dabelea, Mary Helen Black, Elizabeth J. Mayer-Davis, Catherine Pihoker

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    2 Scopus citations

    Abstract

    Background/Aims: In adults, lower vitamin D has been associated with increased albuminuria. This association has not been extensively studied in youth with or without type 1 diabetes. Methods: We examined the cross-sectional association between vitamin D and albuminuria (urine albumin to creatinine ratio ≥30 mg/g) in 8,789 participants of the National Health and Nutrition Survey 2001-2006 (NHANES), who were 6-19 years old. Further, we examined the association between vitamin D and albuminuria in 938 participants from the SEARCH Nutritional Ancillary Study (SNAS), a longitudinal cohort of youth with type 1 diabetes. Results: Of the NHANES participants, 5.3, 19.5, and 53.7% had vitamin D levels <30, 50 and 80 nmol/L, respectively. Albuminuria was present in 12.8% and was more common in younger children, females, non-Hispanic whites, non-obese children, and children with hypertension. After adjustments, there was no association between vitamin D and albuminuria. Among the SNAS participants with type 1 diabetes, we also found no association between baseline vitamin D and subsequent albuminuria in unadjusted or adjusted analyses. Conclusion: We did not find an association between serum vitamin D and albuminuria in either non-diabetic youth or those with type 1 diabetes. Further research is needed to more fully understand this relationship.

    Original languageEnglish (US)
    Pages (from-to)385-395
    Number of pages11
    JournalHormone Research in Paediatrics
    Volume87
    Issue number6
    DOIs
    StatePublished - Jul 1 2017

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    Keywords

    • Adolescents
    • Albuminuria
    • Children
    • Type 1 diabetes
    • Vitamin D

    ASJC Scopus subject areas

    • Pediatrics, Perinatology, and Child Health
    • Endocrinology, Diabetes and Metabolism
    • Endocrinology

    Cite this

    Nandi-Munshi, D., Afkarian, M., Whitlock, K. B., Crandell, J. L., Bell, R. A., D'Agostino, R., Saydah, S., Mottl, A. K., Dabelea, D., Black, M. H., Mayer-Davis, E. J., & Pihoker, C. (2017). Vitamin D and Albuminuria in Youth with and without Type 1 Diabetes. Hormone Research in Paediatrics, 87(6), 385-395. https://doi.org/10.1159/000475711