Vitamin C-enriched gelatin supplementation before intermittent activity augments collagen synthesis

Gregory Shaw, Ann Lee-Barthel, Megan L.R. Ross, Bing Wang, Keith Baar

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Background: Musculoskeletal injuries are the most common complaint in active populations. More than 50% of all injuries in sports can be classified as sprains, strains, ruptures, or breaks of musculoskeletal tissues. Nutritional and/or exercise interventions that increase collagen synthesis and strengthen these tissues could have an important effect on injury rates. Objective: This study was designed to determine whether gelatin supplementation could increase collagen synthesis. Design: Eight healthy male subjects completed a randomized, doubleblinded, crossover-design study in which they consumed either 5 or 15 g of vitamin C-enriched gelatin or a placebo control. After the initial drink, blood was taken every 30 min to determine amino acid content in the blood. A larger blood sample was taken before and 1 h after consumption of gelatin for treatment of engineered ligaments. One hour after the initial supplement, the subjects completed 6 min of rope-skipping to stimulate collagen synthesis. This pattern of supplementation was repeated 3 times/d with ≥6 h between exercise bouts for 3 d. Blood was drawn before and 4, 24, 48, and 72 h after the first exercise bout for determination of amino-terminal propeptide of collagen I content. Results: Supplementation with increasing amounts of gelatin increased circulating glycine, proline, hydroxyproline, and hydroxylysine, peaking 1 h after the supplement was given. Engineered ligaments treated for 6 d with serum from samples collected before or 1 h after subjects consumed a placebo or 5 or 15 g gelatin showed increased collagen content and improved mechanics. Subjects who took 15 g gelatin 1 h before exercise showed double the amino-terminal propeptide of collagen I in their blood, indicating increased collagen synthesis. Conclusion: These data suggest that adding gelatin to an intermittent exercise program improves collagen synthesis and could play a beneficial role in injury prevention and tissue repair. This trial was registered at the Australian New Zealand Clinical Trials Registry as ACTRN12616001092482.

Original languageEnglish (US)
Pages (from-to)136-143
Number of pages8
JournalAmerican Journal of Clinical Nutrition
Volume105
Issue number1
DOIs
StatePublished - Jan 1 2017

Fingerprint

Gelatin
Ascorbic Acid
Collagen
Exercise
Ligaments
Cross-Over Studies
Wounds and Injuries
Placebos
Hydroxylysine
Sprains and Strains
Athletic Injuries
Hydroxyproline
Mechanics
New Zealand
Proline
Glycine
Registries
Rupture
Healthy Volunteers
Clinical Trials

Keywords

  • Bone
  • Exercise
  • Inury prevention
  • Ligament
  • Return to play
  • Tendon

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Vitamin C-enriched gelatin supplementation before intermittent activity augments collagen synthesis. / Shaw, Gregory; Lee-Barthel, Ann; Ross, Megan L.R.; Wang, Bing; Baar, Keith.

In: American Journal of Clinical Nutrition, Vol. 105, No. 1, 01.01.2017, p. 136-143.

Research output: Contribution to journalArticle

Shaw, Gregory ; Lee-Barthel, Ann ; Ross, Megan L.R. ; Wang, Bing ; Baar, Keith. / Vitamin C-enriched gelatin supplementation before intermittent activity augments collagen synthesis. In: American Journal of Clinical Nutrition. 2017 ; Vol. 105, No. 1. pp. 136-143.
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