Vitamin B12 deficiency, tumor necrosis factor-α, and epidermal growth factor: A novel function for vitamin B12?

Joshua W. Miller

Research output: Contribution to journalArticle

22 Scopus citations


Vitamin B12 deficiency was recently shown to be associated with elevated levels of tumor necrosis factor-α and decreased levels of epidermal growth factor in both rats and humans. These findings suggest a novel pathogenetic mechanism underlying the neuropathology of vitamin B12 deficiency. They may also explain putative relationships between vitamin B12 deficiency and certain disorders, including Alzheimer's disease, rheumatoid arthritis, and AIDS.

Original languageEnglish (US)
Pages (from-to)142-144
Number of pages3
JournalNutrition Reviews
Issue number5 I
StatePublished - 2002
Externally publishedYes



  • AIDS
  • Alzheimer's
  • Epidermal growth factor
  • Rheumatoid arthritis
  • Tumor necrosis factor-α
  • Vitamin B deficiency

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

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