Vitamin B Regulation of Alcoholic Liver Disease

Charles H. Halsted, Valentina Medici

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Chronic alcoholism may result in generalized malnutrition with multiple vitamin deficiencies. Folate, vitamin B12, and vitamin B6 are involved in the pathogenesis of alcoholic liver disease through their effects on hepatic methionine metabolism that regulates methylation potential and epigenetic control over the expressions of genes involved in alcoholic liver injury. This chapter focuses first on the effects of chronic alcoholism on metabolism and maintenance of these three vitamins, and their roles in hepatic methionine metabolism; second, on the interactions of hepatic methionine metabolism in the pathogenesis of alcoholic liver disease; and third, on evidence for epigenetic regulation of the pathogenesis of alcoholic liver disease through changes in vitamin dependent methylation of relevant genes.

Original languageEnglish (US)
Title of host publicationMolecular Aspects of Alcohol and Nutrition: A Volume in the Molecular Nutrition Series
PublisherElsevier Inc.
Pages95-106
Number of pages12
ISBN (Electronic)9780128010037
ISBN (Print)9780128007730
DOIs
StatePublished - Jan 1 2015

Keywords

  • Alcoholism
  • Epigenetic
  • Folate
  • Liver disease
  • Methylation
  • Vitamin B12
  • Vitamin B6

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Halsted, C. H., & Medici, V. (2015). Vitamin B Regulation of Alcoholic Liver Disease. In Molecular Aspects of Alcohol and Nutrition: A Volume in the Molecular Nutrition Series (pp. 95-106). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-800773-0.00008-2