Vitamin A is excreted in the urine during acute infection

Charles B. Stephensen, José O. Alvarez, Jorge Kohatsu, Rosemarie Hardmeier, John I. Kennedy, R. Bruce Gammon

Research output: Contribution to journalArticle

196 Scopus citations

Abstract

Episodes of acute infection are thought to deplete body stores of vitamin A. The mechanism by which this might occur is not known, but increased metabolic requirements are presumed to play a role. We have found, however, that significant amounts of retinol and retinol-binding protein (RBP) were excreted in the urine during serious infections, whereas only trace amounts were found in the urine of healthy control subjects. The geometric mean excretion rate in 29 subjects with pneumonia and sepsis was 0.78 μmol retinol/d. Subjects with fever (temperature ≥ 38.3°C) excreted significantly more retinol (geometric x̄ = 1.67 μmol/d) than did those without fever (0.18 μmol/d; t = 3.53, P < 0.0015). Aminoglycoside administration and low glomerular filtration rates (< 35 mL/min) were also associated with higher rates of urinary retinol excretion. Thirty-four percent of patients excreted > 1.75 μmol retinol/d, equivalent to 50% of the US recommended dietary allowance. These data show that vitamin A requirements are substantially increased during serious infections because of excretion of retinol in the urine, and suggest that these losses are due to pathologic changes associated with the febrile response.

Original languageEnglish (US)
Pages (from-to)388-392
Number of pages5
JournalAmerican Journal of Clinical Nutrition
Volume60
Issue number3
StatePublished - Sep 1994
Externally publishedYes

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

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    Stephensen, C. B., Alvarez, J. O., Kohatsu, J., Hardmeier, R., Kennedy, J. I., & Gammon, R. B. (1994). Vitamin A is excreted in the urine during acute infection. American Journal of Clinical Nutrition, 60(3), 388-392.