Vitamin A deficiency impairs some aspects of the host response to influenza A virus infection in BALB/c mice

C. B. Stephensen, S. R. Blount, T. R. Schoeb, J. Y. Park

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

We examined the impact of vitamin A deficiency on the host response to an acute, viral infection of the respiratory tract by infecting BALB/c mice with a mouse-adapted strain of influenza A virus. Several indicators of the severity of infection were examined, including the rate of virus clearance from the lungs, the extent of inflammatory lesions, and percentage of survival. None of these was affected by vitamin A deficiency. Following the acute phase of infection, however, the regeneration of normal, respiratory epithelium was impaired and adenomatoid, metaplastic lesions developed within inflammatory foci in the lungs of deficient animals. The antibody response to infection was also characterized: the influenza A-specific immunoglobulin A (IgA) response in the respiratory tract was markedly decreased by vitamin A deficiency, but tracheal and lung lavage IgG titers were not affected. The serum IgM and IgG responses, and the serum hemagglutination-inhibition response, were also diminished by vitamin A deficiency. Decreased mucosal IgA titers and impaired regeneration of normal respiratory epithelium could impair recovery from a primary infection and increase susceptibility to opportunistic secondary infections.

Original languageEnglish (US)
Pages (from-to)823-833
Number of pages11
JournalJournal of Nutrition
Volume123
Issue number5
StatePublished - 1993
Externally publishedYes

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Vitamin A Deficiency
vitamin A deficiency
Influenza A virus
Virus Diseases
respiratory mucosa
immunoglobulin A
Respiratory Mucosa
lungs
mice
Infection
lesions (animal)
infection
Respiratory System
Immunoglobulin A
Regeneration
Immunoglobulin G
Lung
Opportunistic Infections
Hemagglutination
Bronchoalveolar Lavage

Keywords

  • immunoglobulin
  • influenza A virus
  • metaplasia
  • mice
  • vitamin A deficiency

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

Cite this

Stephensen, C. B., Blount, S. R., Schoeb, T. R., & Park, J. Y. (1993). Vitamin A deficiency impairs some aspects of the host response to influenza A virus infection in BALB/c mice. Journal of Nutrition, 123(5), 823-833.

Vitamin A deficiency impairs some aspects of the host response to influenza A virus infection in BALB/c mice. / Stephensen, C. B.; Blount, S. R.; Schoeb, T. R.; Park, J. Y.

In: Journal of Nutrition, Vol. 123, No. 5, 1993, p. 823-833.

Research output: Contribution to journalArticle

Stephensen, CB, Blount, SR, Schoeb, TR & Park, JY 1993, 'Vitamin A deficiency impairs some aspects of the host response to influenza A virus infection in BALB/c mice', Journal of Nutrition, vol. 123, no. 5, pp. 823-833.
Stephensen, C. B. ; Blount, S. R. ; Schoeb, T. R. ; Park, J. Y. / Vitamin A deficiency impairs some aspects of the host response to influenza A virus infection in BALB/c mice. In: Journal of Nutrition. 1993 ; Vol. 123, No. 5. pp. 823-833.
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