Vitamin A and retinoids in antiviral responses

A. Catharine Ross, Charles B. Stephensen

Research output: Contribution to journalArticle

86 Scopus citations

Abstract

Vitamin A deficiency results in multiple derangements that impair the response to infection. This review focuses on experimental models of specific virus infections and oil cytokines and cells with cytolytic activity important to antiviral defenses. Altered specific antibody responses and greater epithelial damage in vitamin A-deficient hosts are consistent findings. The cytolytic activity of natural killer cells and various cytokine responses are altered. The inflammatory response to infection may also result in derangements in the transport and metabolism of retinol. We speculate that interaction of several factors may combine to explain the greater severity of infection seen in vitamin A-deficient animals and children. In addition to a preexisting lack of tissue vitamin A, these factors may include reduced mobilization and increased excretion of retinol during the acute phase response to infection, poor innate and specific immune response to virus, and delayed repair of damaged epithelia. Foci of vitamin A-deficient epithelia may be sites of penetration of bacteria and other agents, leading to secondary infections and contributing to an increased severity of infections and poor outcome in vitamin A-deficient animals and humans.

Original languageEnglish (US)
Pages (from-to)979-985
Number of pages7
JournalFASEB Journal
Volume10
Issue number9
StatePublished - 1996
Externally publishedYes

Keywords

  • cytokines
  • Herpes simplex virus
  • natural killer cells
  • Newcastle disease virus
  • retinol binding protein
  • vitamin A status

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

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  • Cite this

    Catharine Ross, A., & Stephensen, C. B. (1996). Vitamin A and retinoids in antiviral responses. FASEB Journal, 10(9), 979-985.