Visuospatial and numerical cognitive deficits in children with chromosome 22q11.2 deletion syndrome

Tony J Simon, Carrie E. Bearden, Donna McDonald Mc-Ginn, Elaine Zackai

Research output: Contribution to journalArticle

114 Scopus citations

Abstract

This article presents some of the earliest evidence of visuospatial and numerical cognitive deficits in children with the chromosome 22q11.2 deletion syndrome; a common but ill-understood genetic disorder resulting in medical complications, cognitive impairment, and brain morphologic changes. Relative to a group of typically developing controls, deleted children performed more poorly on tests of visual attentional orienting, visual enumeration and relative numerical magnitude judgment. Results showed that performance deficits in children with the deletion could not be explained by a global deficit in psychomotor speed. Instead, our findings are supportive of the hypothesis that visuospatial and numerical deficits in children with the chromosome 22q11.2 deletion are due, at least in part, to posterior parietal dysfunction.

Original languageEnglish (US)
Pages (from-to)145-155
Number of pages11
JournalCortex
Volume41
Issue number2
StatePublished - Apr 2005
Externally publishedYes

Keywords

  • Attention
  • Child
  • Chromosome 22q11.2
  • Enumeration
  • Judgment
  • Magnitude
  • Parietal lobe
  • VCFS

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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    Simon, T. J., Bearden, C. E., McDonald Mc-Ginn, D., & Zackai, E. (2005). Visuospatial and numerical cognitive deficits in children with chromosome 22q11.2 deletion syndrome. Cortex, 41(2), 145-155.