Visualizing CaMKII and CaM activity: A paradigm of compartmentalized signaling

Julie B C Bossuyt; Donald M Bers

doi:10.1007/s00109-013-1060-y

Visualizing CaMKII and CaM activity: A paradigm of compartmentalized signaling

Julie B C Bossuyt, Donald M Bers

Pharmacology

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Calcium (Ca²⁺) has long been recognized as a crucial intracellular messenger attaining stimuli-specific cellular outcomes via localized signaling. Ca²⁺-binding proteins, such as calmodulin (CaM), and its target proteins are key to the segregation and refinement of these Ca²⁺-dependent signaling events. This review not only summarizes the recent technological advances enabling the study of subcellular Ca ²⁺-CaM and Ca²⁺-CaM-dependent protein kinase (CaMKII) signaling events but also highlights the outstanding challenges in the field.

Original language	English (US)
Pages (from-to)	907-916
Number of pages	10
Journal	Journal of Molecular Medicine
Volume	91
Issue number	8
DOIs	https://doi.org/10.1007/s00109-013-1060-y
State	Published - Aug 2013

Keywords

Ca-calmodulin-dependent protein kinase II (CaMKII)
Calcium
Calmodulin

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery
Genetics(clinical)

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AB - Calcium (Ca2+) has long been recognized as a crucial intracellular messenger attaining stimuli-specific cellular outcomes via localized signaling. Ca2+-binding proteins, such as calmodulin (CaM), and its target proteins are key to the segregation and refinement of these Ca2+-dependent signaling events. This review not only summarizes the recent technological advances enabling the study of subcellular Ca 2+-CaM and Ca2+-CaM-dependent protein kinase (CaMKII) signaling events but also highlights the outstanding challenges in the field.

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