Abstract
Calcium (Ca2+) has long been recognized as a crucial intracellular messenger attaining stimuli-specific cellular outcomes via localized signaling. Ca2+-binding proteins, such as calmodulin (CaM), and its target proteins are key to the segregation and refinement of these Ca2+-dependent signaling events. This review not only summarizes the recent technological advances enabling the study of subcellular Ca 2+-CaM and Ca2+-CaM-dependent protein kinase (CaMKII) signaling events but also highlights the outstanding challenges in the field.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 907-916 |
| Number of pages | 10 |
| Journal | Journal of Molecular Medicine |
| Volume | 91 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 2013 |
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Keywords
- Ca-calmodulin-dependent protein kinase II (CaMKII)
- Calcium
- Calmodulin
ASJC Scopus subject areas
- Molecular Medicine
- Drug Discovery
- Genetics(clinical)
Cite this
Visualizing CaMKII and CaM activity : A paradigm of compartmentalized signaling. / Bossuyt, Julie B C; Bers, Donald M.
In: Journal of Molecular Medicine, Vol. 91, No. 8, 08.2013, p. 907-916.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Visualizing CaMKII and CaM activity
T2 - A paradigm of compartmentalized signaling
AU - Bossuyt, Julie B C
AU - Bers, Donald M
PY - 2013/8
Y1 - 2013/8
N2 - Calcium (Ca2+) has long been recognized as a crucial intracellular messenger attaining stimuli-specific cellular outcomes via localized signaling. Ca2+-binding proteins, such as calmodulin (CaM), and its target proteins are key to the segregation and refinement of these Ca2+-dependent signaling events. This review not only summarizes the recent technological advances enabling the study of subcellular Ca 2+-CaM and Ca2+-CaM-dependent protein kinase (CaMKII) signaling events but also highlights the outstanding challenges in the field.
AB - Calcium (Ca2+) has long been recognized as a crucial intracellular messenger attaining stimuli-specific cellular outcomes via localized signaling. Ca2+-binding proteins, such as calmodulin (CaM), and its target proteins are key to the segregation and refinement of these Ca2+-dependent signaling events. This review not only summarizes the recent technological advances enabling the study of subcellular Ca 2+-CaM and Ca2+-CaM-dependent protein kinase (CaMKII) signaling events but also highlights the outstanding challenges in the field.
KW - Ca-calmodulin-dependent protein kinase II (CaMKII)
KW - Calcium
KW - Calmodulin
UR - http://www.scopus.com/inward/record.url?scp=84881254621&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84881254621&partnerID=8YFLogxK
U2 - 10.1007/s00109-013-1060-y
DO - 10.1007/s00109-013-1060-y
M3 - Article
VL - 91
SP - 907
EP - 916
JO - Journal of Molecular Medicine
JF - Journal of Molecular Medicine
SN - 0946-2716
IS - 8
ER -