Abstract
Calcium (Ca2+) has long been recognized as a crucial intracellular messenger attaining stimuli-specific cellular outcomes via localized signaling. Ca2+-binding proteins, such as calmodulin (CaM), and its target proteins are key to the segregation and refinement of these Ca2+-dependent signaling events. This review not only summarizes the recent technological advances enabling the study of subcellular Ca 2+-CaM and Ca2+-CaM-dependent protein kinase (CaMKII) signaling events but also highlights the outstanding challenges in the field.
Original language | English (US) |
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Pages (from-to) | 907-916 |
Number of pages | 10 |
Journal | Journal of Molecular Medicine |
Volume | 91 |
Issue number | 8 |
DOIs | |
State | Published - Aug 2013 |
Keywords
- Ca-calmodulin-dependent protein kinase II (CaMKII)
- Calcium
- Calmodulin
ASJC Scopus subject areas
- Molecular Medicine
- Drug Discovery
- Genetics(clinical)