Visualizing CaMKII and CaM activity: A paradigm of compartmentalized signaling

Julie B C Bossuyt; Donald M Bers

doi:10.1007/s00109-013-1060-y

Visualizing CaMKII and CaM activity: A paradigm of compartmentalized signaling

Julie B C Bossuyt, Donald M Bers

Pharmacology

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Calcium (Ca²⁺) has long been recognized as a crucial intracellular messenger attaining stimuli-specific cellular outcomes via localized signaling. Ca²⁺-binding proteins, such as calmodulin (CaM), and its target proteins are key to the segregation and refinement of these Ca²⁺-dependent signaling events. This review not only summarizes the recent technological advances enabling the study of subcellular Ca ²⁺-CaM and Ca²⁺-CaM-dependent protein kinase (CaMKII) signaling events but also highlights the outstanding challenges in the field.

Original language	English (US)
Pages (from-to)	907-916
Number of pages	10
Journal	Journal of Molecular Medicine
Volume	91
Issue number	8
DOIs	https://doi.org/10.1007/s00109-013-1060-y
State	Published - Aug 2013

Keywords

Ca-calmodulin-dependent protein kinase II (CaMKII)
Calcium
Calmodulin

ASJC Scopus subject areas

Molecular Medicine
Drug Discovery
Genetics(clinical)

Access to Document

10.1007/s00109-013-1060-y

Fingerprint Dive into the research topics of 'Visualizing CaMKII and CaM activity: A paradigm of compartmentalized signaling'. Together they form a unique fingerprint.

Cite this

@article{b43ca875ad154293973b1ca14335332f,

title = "Visualizing CaMKII and CaM activity: A paradigm of compartmentalized signaling",

abstract = "Calcium (Ca2+) has long been recognized as a crucial intracellular messenger attaining stimuli-specific cellular outcomes via localized signaling. Ca2+-binding proteins, such as calmodulin (CaM), and its target proteins are key to the segregation and refinement of these Ca2+-dependent signaling events. This review not only summarizes the recent technological advances enabling the study of subcellular Ca 2+-CaM and Ca2+-CaM-dependent protein kinase (CaMKII) signaling events but also highlights the outstanding challenges in the field.",

keywords = "Ca-calmodulin-dependent protein kinase II (CaMKII), Calcium, Calmodulin",

author = "Bossuyt, {Julie B C} and Bers, {Donald M}",

year = "2013",

month = aug,

doi = "10.1007/s00109-013-1060-y",

language = "English (US)",

volume = "91",

pages = "907--916",

journal = "Clinical Investigator",

issn = "0946-2716",

publisher = "Springer Verlag",

number = "8",

}

TY - JOUR

T1 - Visualizing CaMKII and CaM activity

T2 - A paradigm of compartmentalized signaling

AU - Bossuyt, Julie B C

AU - Bers, Donald M

PY - 2013/8

Y1 - 2013/8

N2 - Calcium (Ca2+) has long been recognized as a crucial intracellular messenger attaining stimuli-specific cellular outcomes via localized signaling. Ca2+-binding proteins, such as calmodulin (CaM), and its target proteins are key to the segregation and refinement of these Ca2+-dependent signaling events. This review not only summarizes the recent technological advances enabling the study of subcellular Ca 2+-CaM and Ca2+-CaM-dependent protein kinase (CaMKII) signaling events but also highlights the outstanding challenges in the field.

AB - Calcium (Ca2+) has long been recognized as a crucial intracellular messenger attaining stimuli-specific cellular outcomes via localized signaling. Ca2+-binding proteins, such as calmodulin (CaM), and its target proteins are key to the segregation and refinement of these Ca2+-dependent signaling events. This review not only summarizes the recent technological advances enabling the study of subcellular Ca 2+-CaM and Ca2+-CaM-dependent protein kinase (CaMKII) signaling events but also highlights the outstanding challenges in the field.

KW - Ca-calmodulin-dependent protein kinase II (CaMKII)

KW - Calcium

KW - Calmodulin

UR - http://www.scopus.com/inward/record.url?scp=84881254621&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84881254621&partnerID=8YFLogxK

U2 - 10.1007/s00109-013-1060-y

DO - 10.1007/s00109-013-1060-y

M3 - Article

C2 - 23775230

AN - SCOPUS:84881254621

VL - 91

SP - 907

EP - 916

JO - Clinical Investigator

JF - Clinical Investigator

SN - 0946-2716

IS - 8

ER -

Visualizing CaMKII and CaM activity: A paradigm of compartmentalized signaling

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this