Visualizing CaMKII and CaM activity: A paradigm of compartmentalized signaling

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14 Scopus citations

Abstract

Calcium (Ca2+) has long been recognized as a crucial intracellular messenger attaining stimuli-specific cellular outcomes via localized signaling. Ca2+-binding proteins, such as calmodulin (CaM), and its target proteins are key to the segregation and refinement of these Ca2+-dependent signaling events. This review not only summarizes the recent technological advances enabling the study of subcellular Ca 2+-CaM and Ca2+-CaM-dependent protein kinase (CaMKII) signaling events but also highlights the outstanding challenges in the field.

Original languageEnglish (US)
Pages (from-to)907-916
Number of pages10
JournalJournal of Molecular Medicine
Volume91
Issue number8
DOIs
StatePublished - Aug 2013

Keywords

  • Ca-calmodulin-dependent protein kinase II (CaMKII)
  • Calcium
  • Calmodulin

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery
  • Genetics(clinical)

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