Visualization of human retinal micro-capillaries with phase contrast high-speed optical coherence tomography

Dae Yu Kim, Jeff Fingler, John S Werner, Daniel M. Schwartz, Scott E. Fraser, Robert Zawadzki

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

We present high-speed Fourier-domain optical coherence tomography (Fd-OCT) with the phase variance based motion contrast method for visualizing retinal micro-circulation in vivo. This technique allows non-invasive visualization of a two-dimensional retinal perfusion map and concurrent volumetric morphology of retinal microvasculature with high sensitivity. The high-speed acquisition rate at 125kHz A-scans enables reduction of motion artifacts with increased scanning area if compared to previously reported results. Several scanning schemes with different sampling densities and scanning areas are evaluated to find optimal parameters for in vivo imaging. In order to evaluate this technique, we compare OCT micro-capillary imaging using the phase variance technique with fundus fluorescein angiography (FA). Additionally, volumetric visualization of blood flow for a normal subject is presented.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7889
DOIs
StatePublished - 2011
EventOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV - San Francisco, CA, United States
Duration: Jan 24 2011Jan 26 2011

Other

OtherOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XV
CountryUnited States
CitySan Francisco, CA
Period1/24/111/26/11

Keywords

  • Imaging system
  • Medical optics instrumentation
  • Optical coherence tomography
  • Phase contrast technique

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Kim, D. Y., Fingler, J., Werner, J. S., Schwartz, D. M., Fraser, S. E., & Zawadzki, R. (2011). Visualization of human retinal micro-capillaries with phase contrast high-speed optical coherence tomography. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 7889). [78890H] https://doi.org/10.1117/12.873896