Visualization of human retinal capillary networks: A comparison of intensity, speckle-variance and phase-variance optical coherence tomography

Dae Yu Kim, Jeff Fingler, John S Werner, Daniel M. Schwartz, Scott E. Fraser, Robert Zawadzki

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

We evaluate methods to visualize human retinal micro-circulation in vivo by standard intensity-based optical coherence tomography (OCT), speckle-variance optical coherence tomography (svOCT), and phase-variance optical coherence tomography (pvOCT). En face projection views created from the same volumetric data set of the human retina using all three data processing methods are created and compared. Additionally we used support vector machine (SVM) based semi-automatic segmentation to generate en face projection views of individual retinal layers. The layers include: first, the whole inner retina (from the nerve fiber layer to the outer nuclear layer), and second, from the ganglion cell layer to the outer nuclear layer. Finally, we compare the retinal vasculature images processed from the three OCT techniques and fluorescein angiography (FA).

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
PublisherSPIE
Volume8213
ISBN (Print)9780819488565
DOIs
StatePublished - 2012
EventOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI - San Francisco, CA, United States
Duration: Jan 23 2012Jan 25 2012

Other

OtherOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XVI
CountryUnited States
CitySan Francisco, CA
Period1/23/121/25/12

Keywords

  • Imaging system
  • Medical optics instrumentation
  • Optical coherence tomography
  • Phase contrast technique

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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    Kim, D. Y., Fingler, J., Werner, J. S., Schwartz, D. M., Fraser, S. E., & Zawadzki, R. (2012). Visualization of human retinal capillary networks: A comparison of intensity, speckle-variance and phase-variance optical coherence tomography. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 8213). [821307] SPIE. https://doi.org/10.1117/12.906940