Abstract
The impact of perinatal exposure to environmental tobacco smoke (ETS) on cognitive development is controversial. We exposed rhesus monkeys to ETS or filtered air (5 animals per group) beginning in utero on day 50 of pregnancy and continuing throughout postnatal testing. In infancy, we evaluated both groups for visual recognition memory and auditory function (auditory brainstem response). The ETS group showed significantly less novelty preference in the visual recognition task whereas no effects on auditory function were detected. These preliminary results support the view that perinatal ETS exposure has adverse effects on cognitive function and indicate further that rhesus monkeys may provide a valuable nonhuman primate model for investigating this link.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 102-106 |
| Number of pages | 5 |
| Journal | Brain Research |
| Volume | 1151 |
| Issue number | 1 |
| DOIs | |
| State | Published - Sep 4 2007 |
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Keywords
- Behavior
- Infant
- Monkey
- Perinatal
- Smoking
- Tobacco
ASJC Scopus subject areas
- Neuroscience(all)
- Clinical Neurology
- Developmental Biology
- Molecular Biology
Cite this
Visual recognition memory and auditory brainstem response in infant rhesus monkeys exposed perinatally to environmental tobacco smoke. / Golub, Mari S.; Slotkin, Theodore A.; Tarantal, Alice F; Pinkerton, Kent E.
In: Brain Research, Vol. 1151, No. 1, 04.09.2007, p. 102-106.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Visual recognition memory and auditory brainstem response in infant rhesus monkeys exposed perinatally to environmental tobacco smoke
AU - Golub, Mari S.
AU - Slotkin, Theodore A.
AU - Tarantal, Alice F
AU - Pinkerton, Kent E
PY - 2007/9/4
Y1 - 2007/9/4
N2 - The impact of perinatal exposure to environmental tobacco smoke (ETS) on cognitive development is controversial. We exposed rhesus monkeys to ETS or filtered air (5 animals per group) beginning in utero on day 50 of pregnancy and continuing throughout postnatal testing. In infancy, we evaluated both groups for visual recognition memory and auditory function (auditory brainstem response). The ETS group showed significantly less novelty preference in the visual recognition task whereas no effects on auditory function were detected. These preliminary results support the view that perinatal ETS exposure has adverse effects on cognitive function and indicate further that rhesus monkeys may provide a valuable nonhuman primate model for investigating this link.
AB - The impact of perinatal exposure to environmental tobacco smoke (ETS) on cognitive development is controversial. We exposed rhesus monkeys to ETS or filtered air (5 animals per group) beginning in utero on day 50 of pregnancy and continuing throughout postnatal testing. In infancy, we evaluated both groups for visual recognition memory and auditory function (auditory brainstem response). The ETS group showed significantly less novelty preference in the visual recognition task whereas no effects on auditory function were detected. These preliminary results support the view that perinatal ETS exposure has adverse effects on cognitive function and indicate further that rhesus monkeys may provide a valuable nonhuman primate model for investigating this link.
KW - Behavior
KW - Infant
KW - Monkey
KW - Perinatal
KW - Smoking
KW - Tobacco
UR - http://www.scopus.com/inward/record.url?scp=34248174354&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34248174354&partnerID=8YFLogxK
U2 - 10.1016/j.brainres.2007.03.001
DO - 10.1016/j.brainres.2007.03.001
M3 - Article
C2 - 17399690
AN - SCOPUS:34248174354
VL - 1151
SP - 102
EP - 106
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1
ER -