Visceral pain

Gut microbiota, a new hope? 11 Medical and Health Sciences 1109 Neurosciences 11 Medical and Health Sciences 1103 Clinical Sciences

Matteo M. Pusceddu, Melanie Gareau

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Background: Visceral pain is a complex and heterogeneous disorder, which can range from the mild discomfort of indigestion to the agonizing pain of renal colic. Regulation of visceral pain involves the spinal cord as well as higher order brain structures. Recent findings have linked the microbiota to gastrointestinal disorders characterized by abdominal pain suggesting the ability of microbes to modulate visceral hypersensitivity and nociception to pain. Main body: In this review we describe the neuroanatomical basis of visceral pain signaling and the existing evidence of its manipulation exerted by the gut microbiota. We included an updated overview of the potential therapeutic effects of dietary intervention, specifically probiotics and prebiotics, in alleviating hypersensitivity to visceral pain stimuli. Conclusions: The gut microbiota dramatically impacts normal visceral pain sensation and affects the mechanisms mediating visceral nociception. Furthermore, manipulation of the gut microbiota using prebiotics and probiotics plays a potential role in the regulation of visceral pain disorders.

Original languageEnglish (US)
Article number73
JournalJournal of Biomedical Science
Volume25
Issue number1
DOIs
StatePublished - Oct 11 2018

Fingerprint

Visceral Pain
Prebiotics
Neurosciences
Health
Brain
Nociception
Probiotics
Hypersensitivity
Renal Colic
Pain
Somatoform Disorders
Aptitude
Dyspepsia
Therapeutic Uses
Abdominal Pain
Gastrointestinal Microbiome
Spinal Cord

Keywords

  • Colitis
  • FGID
  • IBS
  • Microbiome
  • Microbiota-gut-brain axis
  • Prebiotics
  • Probiotics
  • Visceral pain

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology
  • Biochemistry, medical
  • Pharmacology (medical)

Cite this

@article{33c91979789b4832a2ffda8da2801230,
title = "Visceral pain: Gut microbiota, a new hope? 11 Medical and Health Sciences 1109 Neurosciences 11 Medical and Health Sciences 1103 Clinical Sciences",
abstract = "Background: Visceral pain is a complex and heterogeneous disorder, which can range from the mild discomfort of indigestion to the agonizing pain of renal colic. Regulation of visceral pain involves the spinal cord as well as higher order brain structures. Recent findings have linked the microbiota to gastrointestinal disorders characterized by abdominal pain suggesting the ability of microbes to modulate visceral hypersensitivity and nociception to pain. Main body: In this review we describe the neuroanatomical basis of visceral pain signaling and the existing evidence of its manipulation exerted by the gut microbiota. We included an updated overview of the potential therapeutic effects of dietary intervention, specifically probiotics and prebiotics, in alleviating hypersensitivity to visceral pain stimuli. Conclusions: The gut microbiota dramatically impacts normal visceral pain sensation and affects the mechanisms mediating visceral nociception. Furthermore, manipulation of the gut microbiota using prebiotics and probiotics plays a potential role in the regulation of visceral pain disorders.",
keywords = "Colitis, FGID, IBS, Microbiome, Microbiota-gut-brain axis, Prebiotics, Probiotics, Visceral pain",
author = "Pusceddu, {Matteo M.} and Melanie Gareau",
year = "2018",
month = "10",
day = "11",
doi = "10.1186/s12929-018-0476-7",
language = "English (US)",
volume = "25",
journal = "Journal of Biomedical Science",
issn = "1021-7770",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - Visceral pain

T2 - Gut microbiota, a new hope? 11 Medical and Health Sciences 1109 Neurosciences 11 Medical and Health Sciences 1103 Clinical Sciences

AU - Pusceddu, Matteo M.

AU - Gareau, Melanie

PY - 2018/10/11

Y1 - 2018/10/11

N2 - Background: Visceral pain is a complex and heterogeneous disorder, which can range from the mild discomfort of indigestion to the agonizing pain of renal colic. Regulation of visceral pain involves the spinal cord as well as higher order brain structures. Recent findings have linked the microbiota to gastrointestinal disorders characterized by abdominal pain suggesting the ability of microbes to modulate visceral hypersensitivity and nociception to pain. Main body: In this review we describe the neuroanatomical basis of visceral pain signaling and the existing evidence of its manipulation exerted by the gut microbiota. We included an updated overview of the potential therapeutic effects of dietary intervention, specifically probiotics and prebiotics, in alleviating hypersensitivity to visceral pain stimuli. Conclusions: The gut microbiota dramatically impacts normal visceral pain sensation and affects the mechanisms mediating visceral nociception. Furthermore, manipulation of the gut microbiota using prebiotics and probiotics plays a potential role in the regulation of visceral pain disorders.

AB - Background: Visceral pain is a complex and heterogeneous disorder, which can range from the mild discomfort of indigestion to the agonizing pain of renal colic. Regulation of visceral pain involves the spinal cord as well as higher order brain structures. Recent findings have linked the microbiota to gastrointestinal disorders characterized by abdominal pain suggesting the ability of microbes to modulate visceral hypersensitivity and nociception to pain. Main body: In this review we describe the neuroanatomical basis of visceral pain signaling and the existing evidence of its manipulation exerted by the gut microbiota. We included an updated overview of the potential therapeutic effects of dietary intervention, specifically probiotics and prebiotics, in alleviating hypersensitivity to visceral pain stimuli. Conclusions: The gut microbiota dramatically impacts normal visceral pain sensation and affects the mechanisms mediating visceral nociception. Furthermore, manipulation of the gut microbiota using prebiotics and probiotics plays a potential role in the regulation of visceral pain disorders.

KW - Colitis

KW - FGID

KW - IBS

KW - Microbiome

KW - Microbiota-gut-brain axis

KW - Prebiotics

KW - Probiotics

KW - Visceral pain

UR - http://www.scopus.com/inward/record.url?scp=85054718617&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85054718617&partnerID=8YFLogxK

U2 - 10.1186/s12929-018-0476-7

DO - 10.1186/s12929-018-0476-7

M3 - Review article

VL - 25

JO - Journal of Biomedical Science

JF - Journal of Biomedical Science

SN - 1021-7770

IS - 1

M1 - 73

ER -