Viruses in diarrhoeic dogs include novel kobuviruses and sapoviruses

Linlin Li, Patricia Pesavento, Tongling Shan, Christian M. Leutenegger, Chunlin Wang, Eric Delwart

Research output: Contribution to journalArticle

97 Citations (Scopus)

Abstract

The close interactions of dogs with humans and surrounding wildlife provide frequent opportunities for cross-species virus transmissions. In order to initiate an unbiased characterization of the eukaryotic viruses in the gut of dogs, this study used deep sequencing of partially purified viral capsid-protected nucleic acids from the faeces of 18 diarrhoeic dogs. Known canine parvoviruses, coronaviruses and rotaviruses were identified, and the genomes of the first reported canine kobuvirus and sapovirus were characterized. Canine kobuvirus, the first sequenced canine picornavirus and the closest genetic relative of the diarrhoea-causing human Aichi virus, was detected at high frequency in the faeces of both healthy and diarrhoeic dogs. Canine sapovirus constituted a novel genogroup within the genus Sapovirus, a group of viruses also associated with human and animal diarrhoea. These results highlight the high frequency of new virus detection possible even in extensively studied animal species using metagenomics approaches, and provide viral genomes for further disease-association studies.

Original languageEnglish (US)
Pages (from-to)2534-2541
Number of pages8
JournalJournal of General Virology
Volume92
Issue number11
DOIs
StatePublished - Nov 2011

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Kobuvirus
Sapovirus
Canidae
Dogs
Viruses
Feces
Diarrhea
Canine Coronavirus
Canine Parvovirus
Picornaviridae
High-Throughput Nucleotide Sequencing
Metagenomics
Rotavirus
Viral Genome
Capsid
Nucleic Acids
Genotype
Genome

ASJC Scopus subject areas

  • Virology

Cite this

Viruses in diarrhoeic dogs include novel kobuviruses and sapoviruses. / Li, Linlin; Pesavento, Patricia; Shan, Tongling; Leutenegger, Christian M.; Wang, Chunlin; Delwart, Eric.

In: Journal of General Virology, Vol. 92, No. 11, 11.2011, p. 2534-2541.

Research output: Contribution to journalArticle

Li, L, Pesavento, P, Shan, T, Leutenegger, CM, Wang, C & Delwart, E 2011, 'Viruses in diarrhoeic dogs include novel kobuviruses and sapoviruses', Journal of General Virology, vol. 92, no. 11, pp. 2534-2541. https://doi.org/10.1099/vir.0.034611-0
Li, Linlin ; Pesavento, Patricia ; Shan, Tongling ; Leutenegger, Christian M. ; Wang, Chunlin ; Delwart, Eric. / Viruses in diarrhoeic dogs include novel kobuviruses and sapoviruses. In: Journal of General Virology. 2011 ; Vol. 92, No. 11. pp. 2534-2541.
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