Abstract
Asthma is a complex inflammatory disease with many triggers. The best understood asthma inflammatory pathways involve signals characterized by peripheral eosinophilia and elevated immunoglobulin E levels (called T2-high or allergic asthma), though other asthma phenotypes exist (eg, T2-low or non-allergic asthma, eosinophilic or neutrophilic-predominant). Common triggers that lead to poor asthma control and exacerbations include respiratory viruses, aeroallergens, house dust, molds, and other organic and inorganic substances. Increasingly recognized non-allergen triggers include tobacco smoke, small particulate matter (eg, PM2.5), and volatile organic compounds. The interaction between respiratory viruses and non-allergen asthma triggers is not well understood, though it is likely a connection exists which may lead to asthma development and/or exacerbations. In this paper we describe common respiratory viruses and non-allergen triggers associated with asthma. In addition, we aim to show the possible interactions, and potential synergy, between viruses and non-allergen triggers. Finally, we introduce a new clinical approach that collects exhaled breath condensates to identify metabolomics associated with viruses and non-allergen triggers that may promote the early management of asthma symptoms.
| Original language | English (US) |
|---|---|
| Journal | Journal of Investigative Medicine |
| DOIs | |
| State | Accepted/In press - Jan 1 2019 |
Fingerprint
Keywords
- asthma
- tobacco
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Viruses and non-allergen environmental triggers in asthma. / Chau-Etchepare, Florence; Hoerger, Joshua L.; Kuhn, Brooks T.; Zeki, Amir A.; Haczku, Angela; Louie, Samuel; Kenyon, Nicholas J.; Davis, Cristina E.; Schivo, Michael.
In: Journal of Investigative Medicine, 01.01.2019.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Viruses and non-allergen environmental triggers in asthma
AU - Chau-Etchepare, Florence
AU - Hoerger, Joshua L.
AU - Kuhn, Brooks T.
AU - Zeki, Amir A.
AU - Haczku, Angela
AU - Louie, Samuel
AU - Kenyon, Nicholas J.
AU - Davis, Cristina E.
AU - Schivo, Michael
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Asthma is a complex inflammatory disease with many triggers. The best understood asthma inflammatory pathways involve signals characterized by peripheral eosinophilia and elevated immunoglobulin E levels (called T2-high or allergic asthma), though other asthma phenotypes exist (eg, T2-low or non-allergic asthma, eosinophilic or neutrophilic-predominant). Common triggers that lead to poor asthma control and exacerbations include respiratory viruses, aeroallergens, house dust, molds, and other organic and inorganic substances. Increasingly recognized non-allergen triggers include tobacco smoke, small particulate matter (eg, PM2.5), and volatile organic compounds. The interaction between respiratory viruses and non-allergen asthma triggers is not well understood, though it is likely a connection exists which may lead to asthma development and/or exacerbations. In this paper we describe common respiratory viruses and non-allergen triggers associated with asthma. In addition, we aim to show the possible interactions, and potential synergy, between viruses and non-allergen triggers. Finally, we introduce a new clinical approach that collects exhaled breath condensates to identify metabolomics associated with viruses and non-allergen triggers that may promote the early management of asthma symptoms.
AB - Asthma is a complex inflammatory disease with many triggers. The best understood asthma inflammatory pathways involve signals characterized by peripheral eosinophilia and elevated immunoglobulin E levels (called T2-high or allergic asthma), though other asthma phenotypes exist (eg, T2-low or non-allergic asthma, eosinophilic or neutrophilic-predominant). Common triggers that lead to poor asthma control and exacerbations include respiratory viruses, aeroallergens, house dust, molds, and other organic and inorganic substances. Increasingly recognized non-allergen triggers include tobacco smoke, small particulate matter (eg, PM2.5), and volatile organic compounds. The interaction between respiratory viruses and non-allergen asthma triggers is not well understood, though it is likely a connection exists which may lead to asthma development and/or exacerbations. In this paper we describe common respiratory viruses and non-allergen triggers associated with asthma. In addition, we aim to show the possible interactions, and potential synergy, between viruses and non-allergen triggers. Finally, we introduce a new clinical approach that collects exhaled breath condensates to identify metabolomics associated with viruses and non-allergen triggers that may promote the early management of asthma symptoms.
KW - asthma
KW - tobacco
UR - http://www.scopus.com/inward/record.url?scp=85070009886&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85070009886&partnerID=8YFLogxK
U2 - 10.1136/jim-2019-001000
DO - 10.1136/jim-2019-001000
M3 - Review article
C2 - 31352362
AN - SCOPUS:85070009886
JO - Journal of Investigative Medicine
JF - Journal of Investigative Medicine
SN - 1081-5589
ER -