Virus-simulating structures in the optic nerve head in Creutzfeldt-Jakob disease

Alan M. Roth, John L Keltner, William G. Ellis, Manuela Martins-Green

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


A 68-year-old man was treated for and died of Creutzfeldt-Jakob disease. At autopsy we found multiple virus-like particles in the optic nerve head, but saw no similar structures in the cornea. Although these particles were morphologically similar to those previously reported in brain, we believe that they are not virions but unrelated cellular structures. We speculate that the causative agents may be naked membrane bound nucleic acids rather than true viruses. We found no optic atrophy or other specific pathologic changes in the eyes; severe occipital cortical degeneration was responsible for the patient's visual loss.

Original languageEnglish (US)
Pages (from-to)827-833
Number of pages7
JournalAmerican Journal of Ophthalmology
Issue number6
StatePublished - 1979

ASJC Scopus subject areas

  • Ophthalmology


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