Abstract
A 68-year-old man was treated for and died of Creutzfeldt-Jakob disease. At autopsy we found multiple virus-like particles in the optic nerve head, but saw no similar structures in the cornea. Although these particles were morphologically similar to those previously reported in brain, we believe that they are not virions but unrelated cellular structures. We speculate that the causative agents may be naked membrane bound nucleic acids rather than true viruses. We found no optic atrophy or other specific pathologic changes in the eyes; severe occipital cortical degeneration was responsible for the patient's visual loss.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 827-833 |
| Number of pages | 7 |
| Journal | American Journal of Ophthalmology |
| Volume | 87 |
| Issue number | 6 |
| State | Published - 1979 |
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ASJC Scopus subject areas
- Ophthalmology
Cite this
Virus-simulating structures in the optic nerve head in Creutzfeldt-Jakob disease. / Roth, Alan M.; Keltner, John L; Ellis, William G.; Martins-Green, Manuela.
In: American Journal of Ophthalmology, Vol. 87, No. 6, 1979, p. 827-833.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Virus-simulating structures in the optic nerve head in Creutzfeldt-Jakob disease
AU - Roth, Alan M.
AU - Keltner, John L
AU - Ellis, William G.
AU - Martins-Green, Manuela
PY - 1979
Y1 - 1979
N2 - A 68-year-old man was treated for and died of Creutzfeldt-Jakob disease. At autopsy we found multiple virus-like particles in the optic nerve head, but saw no similar structures in the cornea. Although these particles were morphologically similar to those previously reported in brain, we believe that they are not virions but unrelated cellular structures. We speculate that the causative agents may be naked membrane bound nucleic acids rather than true viruses. We found no optic atrophy or other specific pathologic changes in the eyes; severe occipital cortical degeneration was responsible for the patient's visual loss.
AB - A 68-year-old man was treated for and died of Creutzfeldt-Jakob disease. At autopsy we found multiple virus-like particles in the optic nerve head, but saw no similar structures in the cornea. Although these particles were morphologically similar to those previously reported in brain, we believe that they are not virions but unrelated cellular structures. We speculate that the causative agents may be naked membrane bound nucleic acids rather than true viruses. We found no optic atrophy or other specific pathologic changes in the eyes; severe occipital cortical degeneration was responsible for the patient's visual loss.
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UR - http://www.scopus.com/inward/citedby.url?scp=0018355447&partnerID=8YFLogxK
M3 - Article
C2 - 377976
AN - SCOPUS:0018355447
VL - 87
SP - 827
EP - 833
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
SN - 0002-9394
IS - 6
ER -