Virus-simulating structures in the optic nerve head in Creutzfeldt-Jakob disease

Alan M. Roth, John L Keltner, William G. Ellis, Manuela Martins-Green

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A 68-year-old man was treated for and died of Creutzfeldt-Jakob disease. At autopsy we found multiple virus-like particles in the optic nerve head, but saw no similar structures in the cornea. Although these particles were morphologically similar to those previously reported in brain, we believe that they are not virions but unrelated cellular structures. We speculate that the causative agents may be naked membrane bound nucleic acids rather than true viruses. We found no optic atrophy or other specific pathologic changes in the eyes; severe occipital cortical degeneration was responsible for the patient's visual loss.

Original languageEnglish (US)
Pages (from-to)827-833
Number of pages7
JournalAmerican Journal of Ophthalmology
Volume87
Issue number6
StatePublished - 1979

Fingerprint

Viral Structures
Creutzfeldt-Jakob Syndrome
Optic Disk
Virion
Optic Atrophy
Cellular Structures
Cornea
Nucleic Acids
Autopsy
Viruses
Membranes
Brain

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Virus-simulating structures in the optic nerve head in Creutzfeldt-Jakob disease. / Roth, Alan M.; Keltner, John L; Ellis, William G.; Martins-Green, Manuela.

In: American Journal of Ophthalmology, Vol. 87, No. 6, 1979, p. 827-833.

Research output: Contribution to journalArticle

Roth, Alan M. ; Keltner, John L ; Ellis, William G. ; Martins-Green, Manuela. / Virus-simulating structures in the optic nerve head in Creutzfeldt-Jakob disease. In: American Journal of Ophthalmology. 1979 ; Vol. 87, No. 6. pp. 827-833.
@article{22c62932db7e40c496c8f0bca5627aee,
title = "Virus-simulating structures in the optic nerve head in Creutzfeldt-Jakob disease",
abstract = "A 68-year-old man was treated for and died of Creutzfeldt-Jakob disease. At autopsy we found multiple virus-like particles in the optic nerve head, but saw no similar structures in the cornea. Although these particles were morphologically similar to those previously reported in brain, we believe that they are not virions but unrelated cellular structures. We speculate that the causative agents may be naked membrane bound nucleic acids rather than true viruses. We found no optic atrophy or other specific pathologic changes in the eyes; severe occipital cortical degeneration was responsible for the patient's visual loss.",
author = "Roth, {Alan M.} and Keltner, {John L} and Ellis, {William G.} and Manuela Martins-Green",
year = "1979",
language = "English (US)",
volume = "87",
pages = "827--833",
journal = "American Journal of Ophthalmology",
issn = "0002-9394",
publisher = "Elsevier USA",
number = "6",

}

TY - JOUR

T1 - Virus-simulating structures in the optic nerve head in Creutzfeldt-Jakob disease

AU - Roth, Alan M.

AU - Keltner, John L

AU - Ellis, William G.

AU - Martins-Green, Manuela

PY - 1979

Y1 - 1979

N2 - A 68-year-old man was treated for and died of Creutzfeldt-Jakob disease. At autopsy we found multiple virus-like particles in the optic nerve head, but saw no similar structures in the cornea. Although these particles were morphologically similar to those previously reported in brain, we believe that they are not virions but unrelated cellular structures. We speculate that the causative agents may be naked membrane bound nucleic acids rather than true viruses. We found no optic atrophy or other specific pathologic changes in the eyes; severe occipital cortical degeneration was responsible for the patient's visual loss.

AB - A 68-year-old man was treated for and died of Creutzfeldt-Jakob disease. At autopsy we found multiple virus-like particles in the optic nerve head, but saw no similar structures in the cornea. Although these particles were morphologically similar to those previously reported in brain, we believe that they are not virions but unrelated cellular structures. We speculate that the causative agents may be naked membrane bound nucleic acids rather than true viruses. We found no optic atrophy or other specific pathologic changes in the eyes; severe occipital cortical degeneration was responsible for the patient's visual loss.

UR - http://www.scopus.com/inward/record.url?scp=0018355447&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018355447&partnerID=8YFLogxK

M3 - Article

C2 - 377976

AN - SCOPUS:0018355447

VL - 87

SP - 827

EP - 833

JO - American Journal of Ophthalmology

JF - American Journal of Ophthalmology

SN - 0002-9394

IS - 6

ER -