Virus-induced inhibition of CD1d1-mediated antigen presentation: Reciprocal regulation by p38 and ERK

Gourapura J. Renukaradhya, Tonya J Roberts Webb, Masood A. Khan, Yin Ling Lin, Wenjun Du, Jacquelyn Gervay-Hague, Randy R. Brutkiewicz

Research output: Contribution to journalArticle

56 Scopus citations

Abstract

A critical component of the host's innate immune response involves lipid Ag presentation by CD1d molecules to NK T cells. In this study we used murine CD1d1-transfected L (L-CD1) cells to study the effect of viruses on CD1d-mediated Ag presentation to NKT cells and found that an infection with vesicular stomatitis and vaccinia (but not lymphocytic choriomeningitis) virus inhibited murine CD1d1-mediated Ag presentation. This was under the reciprocal control of the MAPKs, p38 and ERK, and was due to changes in the intracellular trafficking of CD1d1. The reciprocal regulation of CD1d1-mediatcd Ag presentation by MAPK suggests that the targeting of these pathways is a novel means of immune evasion by viruses.

Original languageEnglish (US)
Pages (from-to)4301-4308
Number of pages8
JournalJournal of Immunology
Volume175
Issue number7
StatePublished - Oct 1 2005

ASJC Scopus subject areas

  • Immunology

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    Renukaradhya, G. J., Webb, T. J. R., Khan, M. A., Lin, Y. L., Du, W., Gervay-Hague, J., & Brutkiewicz, R. R. (2005). Virus-induced inhibition of CD1d1-mediated antigen presentation: Reciprocal regulation by p38 and ERK. Journal of Immunology, 175(7), 4301-4308.