Virulence of tissue culture-propagated canine distemper virus

A. E. Metzler, Robert Higgins, S. Krakowka, A. Koestner

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Virulence of canine distemper virus (CVD) adapted to in vitro growth in vero or bovine cells was determined by inoculation into CDV-susceptible neonatal gnotobiotic dogs. When compared with dogs given virulent R252-CDV, Vero R252-CDV was attenuated at passage level 14. In contrast, dogs inoculated with bovine R252-CDV at the same passage level experienced rapid fatal neurological disease. Virulence was not linked to ability to infect or replicate in canine pulmonary macrophage cultures. Retention of virulence by bovine R252-CDV is unique and worthy of further study.

Original languageEnglish (US)
Pages (from-to)940-944
Number of pages5
JournalInfection and Immunity
Issue number3
StatePublished - Jan 1 1980
Externally publishedYes

ASJC Scopus subject areas

  • Immunology


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