Virtual clinical trials in 3D and 2D breast imaging with digital phantoms derived from clinical breast CT scans

Giovanni Mettivier; Antonio Sarno; John M. Boone; Kristina Bliznakova; Francesca di Franco; Paolo Russo

doi:10.1117/12.2548224

Virtual clinical trials in 3D and 2D breast imaging with digital phantoms derived from clinical breast CT scans

Giovanni Mettivier, Antonio Sarno, John M. Boone, Kristina Bliznakova, Francesca di Franco, Paolo Russo

Radiology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

We are developing a platform for virtual (in silico) clinical trials in x-ray breast imaging and dosimetry fully based on Monte Carlo simulations and which adopts patient-like digital phantoms. We report the initial steps and first results of this project. Our collaboration was established for producing a “user-friendly” computational platform which reproduces both 2D (full-fields digital mammography) and 3D (digital breast tomosynthesis, CT dedicated to the breast) breast imaging examinations for technique optimization and for developing protocols and computed aided diagnostic applications. Dose optimization strategies and technique performance comparisons will be explored. A dataset of anatomically realistic, 2D and 3D digital breast phantoms have been produced by means of voxel classification and digital compression of clinical breast CT scans acquired at UC Davis. Monte Carlo simulations, based on the Geant4 toolkit, have been developed for in-silico FFDM, DBT and BCT examinations.

Original language	English (US)
Title of host publication	Medical Imaging 2020
Subtitle of host publication	Physics of Medical Imaging
Editors	Guang-Hong Chen, Hilde Bosmans
Publisher	SPIE
ISBN (Electronic)	9781510633919
DOIs	https://doi.org/10.1117/12.2548224
State	Published - 2020
Event	Medical Imaging 2020: Physics of Medical Imaging - Houston, United States Duration: Feb 16 2020 → Feb 19 2020

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	11312
ISSN (Print)	1605-7422

Conference

Conference	Medical Imaging 2020: Physics of Medical Imaging
Country	United States
City	Houston
Period	2/16/20 → 2/19/20

Keywords

Monte Carlo simulation
Patien-derived breast phantoms
Virtual Clinical trials
X-ray breast imaging

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Biomaterials
Atomic and Molecular Physics, and Optics
Radiology Nuclear Medicine and imaging

Access to Document

10.1117/12.2548224

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Cite this

Mettivier, G., Sarno, A., Boone, J. M., Bliznakova, K., di Franco, F., & Russo, P. (2020). Virtual clinical trials in 3D and 2D breast imaging with digital phantoms derived from clinical breast CT scans. In G-H. Chen, & H. Bosmans (Eds.), Medical Imaging 2020: Physics of Medical Imaging [1131259] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11312). SPIE. https://doi.org/10.1117/12.2548224

Virtual clinical trials in 3D and 2D breast imaging with digital phantoms derived from clinical breast CT scans. / Mettivier, Giovanni; Sarno, Antonio; Boone, John M.; Bliznakova, Kristina; di Franco, Francesca; Russo, Paolo.

Medical Imaging 2020: Physics of Medical Imaging. ed. / Guang-Hong Chen; Hilde Bosmans. SPIE, 2020. 1131259 (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 11312).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Mettivier, G, Sarno, A, Boone, JM, Bliznakova, K, di Franco, F & Russo, P 2020, Virtual clinical trials in 3D and 2D breast imaging with digital phantoms derived from clinical breast CT scans. in G-H Chen & H Bosmans (eds), Medical Imaging 2020: Physics of Medical Imaging., 1131259, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 11312, SPIE, Medical Imaging 2020: Physics of Medical Imaging, Houston, United States, 2/16/20. https://doi.org/10.1117/12.2548224

Mettivier G, Sarno A, Boone JM, Bliznakova K, di Franco F, Russo P. Virtual clinical trials in 3D and 2D breast imaging with digital phantoms derived from clinical breast CT scans. In Chen G-H, Bosmans H, editors, Medical Imaging 2020: Physics of Medical Imaging. SPIE. 2020. 1131259. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE). https://doi.org/10.1117/12.2548224

Mettivier, Giovanni ; Sarno, Antonio ; Boone, John M. ; Bliznakova, Kristina ; di Franco, Francesca ; Russo, Paolo. / Virtual clinical trials in 3D and 2D breast imaging with digital phantoms derived from clinical breast CT scans. Medical Imaging 2020: Physics of Medical Imaging. editor / Guang-Hong Chen ; Hilde Bosmans. SPIE, 2020. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE).

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