Virological, clinical and serological responses of sheep infected with tissue culture adapted bluetongue virus serotypes 10, 11, 13 and 17

H. W. Ghalib, J. M. Cherrington, Bennie Osburn

Research output: Contribution to journalArticle

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Abstract

Sheep were experimentally infected with cloned strains of tissue culture adapted bluetongue virus (BTV) serotypes 10, 11, 13 and 17. All the infected animals developed viremia by Day 2 or 3 post-inoculation (P.I.) and reached maximum viremia on Day 7 P.I. The viremia lasted for 2 to 3 weeks. Animals infected with the different serotypes showed mild clinical bluetongue (BT) responses, characterized by pyrexia and leukopenia, which coincided with the peak of viremia, Antibodies appeared appeared by Day 10 P.I. and reached maximum by Day 28 P.I. There was a temporal relationship between the increase in neutralizing antibody titer, the drop in titer and clearance of virus from the peripheral circulation. Recovery from primary infection protected the animals against secondary challenge with homologous virus.

Original languageEnglish (US)
Pages (from-to)179-188
Number of pages10
JournalVeterinary Microbiology
Volume10
Issue number2
DOIs
StatePublished - Jan 1 1985

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Bluetongue virus
Viremia
viremia
tissue culture
Sheep
serotypes
sheep
Bluetongue
viruses
animals
leukopenia
bluetongue
Leukopenia
Neutralizing Antibodies
Viral Load
neutralizing antibodies
fever
Fever
Viruses
antibodies

ASJC Scopus subject areas

  • Microbiology
  • veterinary(all)

Cite this

Virological, clinical and serological responses of sheep infected with tissue culture adapted bluetongue virus serotypes 10, 11, 13 and 17. / Ghalib, H. W.; Cherrington, J. M.; Osburn, Bennie.

In: Veterinary Microbiology, Vol. 10, No. 2, 01.01.1985, p. 179-188.

Research output: Contribution to journalArticle

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