Viremia, antigenemia, and serum antibodies in rhesus macaques infected with simian retrovirus type 1 and their relationship to disease course

H. S. Kwang, Niels C Pedersen, N. W. Lerche, K. G. Osborn, P. A. Marx, M. B. Gardner

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Abstract

The course of simian retrovirus type 1 (SRV-1) infection was studied in 14 experimentally inoculated juvenile rhesus monkeys. Viral transmembrane protein antigenemia and antibodies to whole virus were measured by enzyme-linked immunosorbent assay and correlated with the clinical course of disease and virus isolation. Based on these parameters, animals with simian retrovirus type 1-induced disease were divided into three categories: (a) monkeys dying within a few months of fulminating simian acquired immunodeficiency syndrome in the face of a high level persistent antigenemia and viremia, and a nondetectable serum antibody response; (b) monkeys that developed a milder form of simian acquired immunodeficiency syndrome but remained alive in spite of a chronic low-grade antigenemia and viremia and only a transient initial antibody response; and (c) monkeys that never became ill and that were either transiently or nontransiently viremic and antigenemic. This latter group developed high levels of serum antibodies. The outcome of simian retrovirus type 1-induced disease was similar to that described for feline leukemia virus infection of cats, another retroviral disease of animals. The disease course differed considerably, however, from that reported for retrovirus-induced human acquired immunodeficiency syndrome.

Original languageEnglish (US)
Pages (from-to)591-597
Number of pages7
JournalLaboratory Investigation
Volume56
Issue number6
StatePublished - 1987

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Mason-Pfizer monkey virus
Viremia
Simian Acquired Immunodeficiency Syndrome
Macaca mulatta
Haplorhini
Virus Diseases
Antibody Formation
Antibodies
Serum
Retroviridae Infections
Feline Leukemia Virus
Animal Diseases
Viral Proteins
Retroviridae
Acquired Immunodeficiency Syndrome
Cats
Enzyme-Linked Immunosorbent Assay
Viruses

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Viremia, antigenemia, and serum antibodies in rhesus macaques infected with simian retrovirus type 1 and their relationship to disease course. / Kwang, H. S.; Pedersen, Niels C; Lerche, N. W.; Osborn, K. G.; Marx, P. A.; Gardner, M. B.

In: Laboratory Investigation, Vol. 56, No. 6, 1987, p. 591-597.

Research output: Contribution to journalArticle

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