Viral persistence and abnormalities of the central nervous system after congenital infection of sheep with border disease virus

Barbara J. Potts, Laurence J. Berry, Bennie Osburn, Kenneth P. Johnson

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Lambs congenitally infected with border disease (BD) virus and sheep exposed to BD virus as adults were studied for one year to determine the pathogenesis of congenital exposure compared with adult exposure to the virus. Persistent BD virus was isolated in tissue culture and detected by immunofluorescence of the peripheral white blood cells, urine, and cerebrospinal fluid of lambs with congenital BD up to one year of age. These animals had no detectable serum neutralizing antibody response to the virus for the same interval. BD virus antigen was also detected by immunofluorescence in many central nervous system tissues of these lambs with congenital BD. Dysmyelination and glial proliferation in the central nervous system and microencephaly were noted in the lambs with congenital BD, and these lesions appeared to remain the same over a 12-month period.

Original languageEnglish (US)
Pages (from-to)337-343
Number of pages7
JournalJournal of Infectious Diseases
Volume151
Issue number2
DOIs
StatePublished - Jan 1 1985
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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