Viral pathogenesis of a nephrotropic infectious bronchitis virus isolated from commercial pullets.

Hailu Kinde, B. M. Daft, A. E. Castro, A. A. Bickford, J. Gelb, B. Reynolds

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16 Scopus citations

Abstract

Infectious bronchitis was diagnosed in 3-to-4-week-old pullets from an outbreak in a commercial flock in California. The disease was characterized by head swelling, watery discharge from the eyes and nostrils, and urates in kidneys. Mortality ranged from 1.8% to 12.5% per week. The isolation of a coronavirus from a suspension of pooled kidneys from clinically ill chickens at the fifth passage in 10-day-old chicken embryos, gross and histologic renal lesions, and seroconversion by enzyme-linked immunosorbent assay in inoculated birds suggested that the virus isolated was a nephrotrophic strain of infectious bronchitis virus (IBV). The virus isolate was found to be a previously unrecognized serotype, based on virus neutralization tests performed in embryonated chicken eggs. Nephropathogenicity of the IBV isolate was confirmed by inoculation of the viral isolate into specific-pathogen-free chicks and demonstration of renal lesions. The isolation of nephrotropic strains of IBV has not been reported previously from poultry in California.

Original languageEnglish (US)
Pages (from-to)415-421
Number of pages7
JournalAvian Diseases
Volume35
Issue number2
StatePublished - Apr 1991

ASJC Scopus subject areas

  • Cancer Research
  • Immunology
  • veterinary(all)

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    Kinde, H., Daft, B. M., Castro, A. E., Bickford, A. A., Gelb, J., & Reynolds, B. (1991). Viral pathogenesis of a nephrotropic infectious bronchitis virus isolated from commercial pullets. Avian Diseases, 35(2), 415-421.