Veterinary autoimmunity: Autoimmune diseases in domestic animals

Research output: Chapter in Book/Report/Conference proceedingConference contribution

21 Scopus citations


The first spontaneous animal model of autoimmunitywas the New Zealand black mouse, discovered in 1959. Interestingly, although several models of induced autoimmunity were demonstrated in a variety of rodents, the recognition of autoimmune disease in dogs came somewhat later. Dog breeding and selection of traits within certain dog breeds have become an important enterprise with intensive husbandry and selection criteria being applied to each breed standard. This has resulted in breeding for specific phenotypic characteristics. This selection has inadvertently led to the propagation of a number of autoimmune diseases in dogs. For example, systemic lupus erythematosus (SLE), autoimmune hemolytic anemia and thrombocytopenia, autoimmunemyasthenia gravis, and diabetes mellitus are now fairly common. In the final analysis, the appearance of autoimmunity in dogs reflects their breeding selection and illustrates the importance of genetics in the development of autoimmune disease.

Original languageEnglish (US)
Title of host publicationAnnals of the New York Academy of Sciences
Number of pages8
StatePublished - Aug 2007

Publication series

NameAnnals of the New York Academy of Sciences
ISSN (Print)00778923
ISSN (Electronic)17496632


  • Antinuclear antibody
  • Autoimmune disease
  • Canine
  • Case reports
  • Equine
  • Feline
  • Immune-mediated disease
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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