Vessel network formation in response to intermittent hypoxia is frequency dependent

Seema M. Ehsan, Steven George

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

A combined experimental and mathematical model of intermittent hypoxia (IH) conditioned engineered tissue was used to characterize the effects of IH on the formation of in vitro vascular networks. Results showed that the frequency of hypoxic oscillations has pronounced influence on the vascular response of endothelial cells and fibroblasts.

Original languageEnglish (US)
Pages (from-to)347-350
Number of pages4
JournalJournal of Bioscience and Bioengineering
Volume120
Issue number3
DOIs
StatePublished - Sep 1 2015

Keywords

  • 3D culture
  • Endothelial cells
  • Intermittent hypoxia
  • Oxygen
  • Vascular endothelial growth factor
  • Vasculogenesis

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

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