A combined experimental and mathematical model of intermittent hypoxia (IH) conditioned engineered tissue was used to characterize the effects of IH on the formation of in vitro vascular networks. Results showed that the frequency of hypoxic oscillations has pronounced influence on the vascular response of endothelial cells and fibroblasts.
- 3D culture
- Endothelial cells
- Intermittent hypoxia
- Vascular endothelial growth factor
ASJC Scopus subject areas
- Applied Microbiology and Biotechnology