Vesiculopustular eruption associated with transient myeloproliferative disorder

Erika Nornhold, Anna Li, Ilene L. Rothman, Satyanarayana Lakshminrusimha, Thomas N. Helm

Research output: Contribution to journalComment/debate

5 Scopus citations

Abstract

Transient myeloproliferative disorder (TMD) is a hematologic abnormality usually associated with Down syndrome that may present with a skin eruption in addition to typical systemic findings. We report a case of a patient with TMD and a vesiculopustular eruption without the phenotypic characteristics of Down syndrome who was found to have mosaic trisomy 21. Mutations of the globin transcription factor 1 gene, GATA1, are associated with both TMD and acute megakaryocytic leukemia. Transient myeloproliferative disorder typically resents with pancytopenia, hepatosplenomegaly, and immature circulating white blood cells, and affects approximately 10% of neonates with Down syndrome. These abnormalities rapidly regress within the first few months of life. However, 20% to 30% of neonates with Down syndrome and TMD later develop leukemia. The tumor antigen PRAME (preferentially expressed antigen in melanoma) may serve as a marker for leukemic transformation. We report an illustrative case to alert clinicians about this uncommon cause of esiculopustular eruption in a neonate without the phenotypic characteristics of Down syndrome and review the clinical findings and laboratory studies that aid in accurate diagnosis.

Original languageEnglish (US)
Pages (from-to)234-236
Number of pages3
JournalCutis
Volume83
Issue number5
StatePublished - May 1 2009
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology

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    Nornhold, E., Li, A., Rothman, I. L., Lakshminrusimha, S., & Helm, T. N. (2009). Vesiculopustular eruption associated with transient myeloproliferative disorder. Cutis, 83(5), 234-236.