Vesiculopustular eruption associated with transient myeloproliferative disorder

Erika Nornhold, Anna Li, Ilene L. Rothman, Satyanarayana Lakshminrusimha, Thomas N. Helm

Research output: Contribution to journalComment/debate

5 Citations (Scopus)

Abstract

Transient myeloproliferative disorder (TMD) is a hematologic abnormality usually associated with Down syndrome that may present with a skin eruption in addition to typical systemic findings. We report a case of a patient with TMD and a vesiculopustular eruption without the phenotypic characteristics of Down syndrome who was found to have mosaic trisomy 21. Mutations of the globin transcription factor 1 gene, GATA1, are associated with both TMD and acute megakaryocytic leukemia. Transient myeloproliferative disorder typically resents with pancytopenia, hepatosplenomegaly, and immature circulating white blood cells, and affects approximately 10% of neonates with Down syndrome. These abnormalities rapidly regress within the first few months of life. However, 20% to 30% of neonates with Down syndrome and TMD later develop leukemia. The tumor antigen PRAME (preferentially expressed antigen in melanoma) may serve as a marker for leukemic transformation. We report an illustrative case to alert clinicians about this uncommon cause of esiculopustular eruption in a neonate without the phenotypic characteristics of Down syndrome and review the clinical findings and laboratory studies that aid in accurate diagnosis.

Original languageEnglish (US)
Pages (from-to)234-236
Number of pages3
JournalCutis
Volume83
Issue number5
StatePublished - May 1 2009
Externally publishedYes

Fingerprint

Myeloproliferative Disorders
Down Syndrome
Newborn Infant
GATA1 Transcription Factor
Leukemia, Megakaryoblastic, Acute
Melanoma-Specific Antigens
Pancytopenia
Neoplasm Antigens
Leukemia
Leukocytes
Skin
Mutation
Genes

ASJC Scopus subject areas

  • Dermatology

Cite this

Nornhold, E., Li, A., Rothman, I. L., Lakshminrusimha, S., & Helm, T. N. (2009). Vesiculopustular eruption associated with transient myeloproliferative disorder. Cutis, 83(5), 234-236.

Vesiculopustular eruption associated with transient myeloproliferative disorder. / Nornhold, Erika; Li, Anna; Rothman, Ilene L.; Lakshminrusimha, Satyanarayana; Helm, Thomas N.

In: Cutis, Vol. 83, No. 5, 01.05.2009, p. 234-236.

Research output: Contribution to journalComment/debate

Nornhold, E, Li, A, Rothman, IL, Lakshminrusimha, S & Helm, TN 2009, 'Vesiculopustular eruption associated with transient myeloproliferative disorder', Cutis, vol. 83, no. 5, pp. 234-236.
Nornhold, Erika ; Li, Anna ; Rothman, Ilene L. ; Lakshminrusimha, Satyanarayana ; Helm, Thomas N. / Vesiculopustular eruption associated with transient myeloproliferative disorder. In: Cutis. 2009 ; Vol. 83, No. 5. pp. 234-236.
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