Vertical transmission of hepatitis C virus

M. M. Thaler, D. W. Wara, G. Veereman-Wauters, D. V. Landers, Richard L Sweet, C. K. Park, M. Houghton, J. H. Han

Research output: Contribution to journalArticle

237 Citations (Scopus)

Abstract

There is evidence that hepatitis C virus (HCV) may be vertically transmitted from infected mothers to their children. To test this hypothesis, we prospectively studied 10 pregnant women at high risk from parenterally or sexually transmitted diseases with the polymerase chain reaction. HCV RNA was found in 8 newborn babies delivered by women who were anti-HCV seropositive, and persisted for 2-19 months of follow-up. Anti-HCV detected in 7 infants cleared by 9 months and remained undetectable thereafter. Serum alanine aminotransferase was raised in 3 infants. The findings provide evidence of vertical transmission of HCV and suggest that perinatal infection may initiate a silent disease process or chronic carrier state.

Original languageEnglish (US)
Pages (from-to)17-18
Number of pages2
JournalThe Lancet
Volume338
Issue number8758
DOIs
StatePublished - Jul 6 1991

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Hepacivirus
Carrier State
Sexually Transmitted Diseases
Alanine Transaminase
Pregnant Women
Mothers
Newborn Infant
RNA
Polymerase Chain Reaction
Infection
Serum

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Thaler, M. M., Wara, D. W., Veereman-Wauters, G., Landers, D. V., Sweet, R. L., Park, C. K., ... Han, J. H. (1991). Vertical transmission of hepatitis C virus. The Lancet, 338(8758), 17-18. https://doi.org/10.1016/0140-6736(91)90006-B

Vertical transmission of hepatitis C virus. / Thaler, M. M.; Wara, D. W.; Veereman-Wauters, G.; Landers, D. V.; Sweet, Richard L; Park, C. K.; Houghton, M.; Han, J. H.

In: The Lancet, Vol. 338, No. 8758, 06.07.1991, p. 17-18.

Research output: Contribution to journalArticle

Thaler, MM, Wara, DW, Veereman-Wauters, G, Landers, DV, Sweet, RL, Park, CK, Houghton, M & Han, JH 1991, 'Vertical transmission of hepatitis C virus', The Lancet, vol. 338, no. 8758, pp. 17-18. https://doi.org/10.1016/0140-6736(91)90006-B
Thaler MM, Wara DW, Veereman-Wauters G, Landers DV, Sweet RL, Park CK et al. Vertical transmission of hepatitis C virus. The Lancet. 1991 Jul 6;338(8758):17-18. https://doi.org/10.1016/0140-6736(91)90006-B
Thaler, M. M. ; Wara, D. W. ; Veereman-Wauters, G. ; Landers, D. V. ; Sweet, Richard L ; Park, C. K. ; Houghton, M. ; Han, J. H. / Vertical transmission of hepatitis C virus. In: The Lancet. 1991 ; Vol. 338, No. 8758. pp. 17-18.
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