Verbal memory and brain aging: An exploratory analysis of the role of error responses in the Framingham study

David J. Libon, Sarah R. Preis, Alexa S. Beiser, Sherral Devine, Sudha Seshadri, Philip A. Wolf, Charles DeCarli, Rhoda Au

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective: Analysis sought to determine whether Wechsler Memory Scale-Logical Memory (LM)-correct responses and errors were related to magnetic resonance imaging (MRI) brain volume measurements. Methods: The LM immediate (LM-I) and LM delay (LM-D) free recall correct responses and related and unrelated errors were scored. Principal components analysis yielded a 3-factor solution: LM-I and LM-D correct responses, LM-I and LM-D-unrelated errors, and LM-I/-D-related errors. The MRI total cerebral brain volume, frontal brain volume, temporal horn volume (THV), and white matter hyperintensities volume (WMHIV) were obtained. Results: Increasing THV (suggesting greater regional atrophy) was associated with lower scores on the LM-correct responses factor. Extensive WMHIV was associated with higher scores on the LM-related errors factor. Conclusion: These results suggest that LM-correct responses could relate to emerging brain alterations. Longitudinal research might enhance the sensitivity of this test to identify preclinical impairment and persons at risk of mild cognitive impairment and dementia.

Original languageEnglish (US)
Pages (from-to)622-628
Number of pages7
JournalAmerican Journal of Alzheimer's Disease and other Dementias
Volume30
Issue number6
DOIs
StatePublished - Sep 13 2015

Fingerprint

Brain
Temporal Lobe
Magnetic Resonance Imaging
Wechsler Scales
Principal Component Analysis
Short-Term Memory
Atrophy
Dementia
Research

Keywords

  • Alzheimer's disease
  • Boston process approach
  • declarative memory
  • Logical Memory
  • preclinical dementia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology

Cite this

Verbal memory and brain aging : An exploratory analysis of the role of error responses in the Framingham study. / Libon, David J.; Preis, Sarah R.; Beiser, Alexa S.; Devine, Sherral; Seshadri, Sudha; Wolf, Philip A.; DeCarli, Charles; Au, Rhoda.

In: American Journal of Alzheimer's Disease and other Dementias, Vol. 30, No. 6, 13.09.2015, p. 622-628.

Research output: Contribution to journalArticle

Libon, David J. ; Preis, Sarah R. ; Beiser, Alexa S. ; Devine, Sherral ; Seshadri, Sudha ; Wolf, Philip A. ; DeCarli, Charles ; Au, Rhoda. / Verbal memory and brain aging : An exploratory analysis of the role of error responses in the Framingham study. In: American Journal of Alzheimer's Disease and other Dementias. 2015 ; Vol. 30, No. 6. pp. 622-628.
@article{bab78ed3b3674711b2ac0a1ca39ebac5,
title = "Verbal memory and brain aging: An exploratory analysis of the role of error responses in the Framingham study",
abstract = "Objective: Analysis sought to determine whether Wechsler Memory Scale-Logical Memory (LM)-correct responses and errors were related to magnetic resonance imaging (MRI) brain volume measurements. Methods: The LM immediate (LM-I) and LM delay (LM-D) free recall correct responses and related and unrelated errors were scored. Principal components analysis yielded a 3-factor solution: LM-I and LM-D correct responses, LM-I and LM-D-unrelated errors, and LM-I/-D-related errors. The MRI total cerebral brain volume, frontal brain volume, temporal horn volume (THV), and white matter hyperintensities volume (WMHIV) were obtained. Results: Increasing THV (suggesting greater regional atrophy) was associated with lower scores on the LM-correct responses factor. Extensive WMHIV was associated with higher scores on the LM-related errors factor. Conclusion: These results suggest that LM-correct responses could relate to emerging brain alterations. Longitudinal research might enhance the sensitivity of this test to identify preclinical impairment and persons at risk of mild cognitive impairment and dementia.",
keywords = "Alzheimer's disease, Boston process approach, declarative memory, Logical Memory, preclinical dementia",
author = "Libon, {David J.} and Preis, {Sarah R.} and Beiser, {Alexa S.} and Sherral Devine and Sudha Seshadri and Wolf, {Philip A.} and Charles DeCarli and Rhoda Au",
year = "2015",
month = "9",
day = "13",
doi = "10.1177/1533317515577184",
language = "English (US)",
volume = "30",
pages = "622--628",
journal = "American Journal of Alzheimer's Disease and other Dementias",
issn = "1533-3175",
publisher = "SAGE Publications Inc.",
number = "6",

}

TY - JOUR

T1 - Verbal memory and brain aging

T2 - An exploratory analysis of the role of error responses in the Framingham study

AU - Libon, David J.

AU - Preis, Sarah R.

AU - Beiser, Alexa S.

AU - Devine, Sherral

AU - Seshadri, Sudha

AU - Wolf, Philip A.

AU - DeCarli, Charles

AU - Au, Rhoda

PY - 2015/9/13

Y1 - 2015/9/13

N2 - Objective: Analysis sought to determine whether Wechsler Memory Scale-Logical Memory (LM)-correct responses and errors were related to magnetic resonance imaging (MRI) brain volume measurements. Methods: The LM immediate (LM-I) and LM delay (LM-D) free recall correct responses and related and unrelated errors were scored. Principal components analysis yielded a 3-factor solution: LM-I and LM-D correct responses, LM-I and LM-D-unrelated errors, and LM-I/-D-related errors. The MRI total cerebral brain volume, frontal brain volume, temporal horn volume (THV), and white matter hyperintensities volume (WMHIV) were obtained. Results: Increasing THV (suggesting greater regional atrophy) was associated with lower scores on the LM-correct responses factor. Extensive WMHIV was associated with higher scores on the LM-related errors factor. Conclusion: These results suggest that LM-correct responses could relate to emerging brain alterations. Longitudinal research might enhance the sensitivity of this test to identify preclinical impairment and persons at risk of mild cognitive impairment and dementia.

AB - Objective: Analysis sought to determine whether Wechsler Memory Scale-Logical Memory (LM)-correct responses and errors were related to magnetic resonance imaging (MRI) brain volume measurements. Methods: The LM immediate (LM-I) and LM delay (LM-D) free recall correct responses and related and unrelated errors were scored. Principal components analysis yielded a 3-factor solution: LM-I and LM-D correct responses, LM-I and LM-D-unrelated errors, and LM-I/-D-related errors. The MRI total cerebral brain volume, frontal brain volume, temporal horn volume (THV), and white matter hyperintensities volume (WMHIV) were obtained. Results: Increasing THV (suggesting greater regional atrophy) was associated with lower scores on the LM-correct responses factor. Extensive WMHIV was associated with higher scores on the LM-related errors factor. Conclusion: These results suggest that LM-correct responses could relate to emerging brain alterations. Longitudinal research might enhance the sensitivity of this test to identify preclinical impairment and persons at risk of mild cognitive impairment and dementia.

KW - Alzheimer's disease

KW - Boston process approach

KW - declarative memory

KW - Logical Memory

KW - preclinical dementia

UR - http://www.scopus.com/inward/record.url?scp=84939187877&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84939187877&partnerID=8YFLogxK

U2 - 10.1177/1533317515577184

DO - 10.1177/1533317515577184

M3 - Article

C2 - 25788434

AN - SCOPUS:84939187877

VL - 30

SP - 622

EP - 628

JO - American Journal of Alzheimer's Disease and other Dementias

JF - American Journal of Alzheimer's Disease and other Dementias

SN - 1533-3175

IS - 6

ER -