Verbal memory and brain aging: An exploratory analysis of the role of error responses in the Framingham study

David J. Libon, Sarah R. Preis, Alexa S. Beiser, Sherral Devine, Sudha Seshadri, Philip A. Wolf, Charles DeCarli, Rhoda Au

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Objective: Analysis sought to determine whether Wechsler Memory Scale-Logical Memory (LM)-correct responses and errors were related to magnetic resonance imaging (MRI) brain volume measurements. Methods: The LM immediate (LM-I) and LM delay (LM-D) free recall correct responses and related and unrelated errors were scored. Principal components analysis yielded a 3-factor solution: LM-I and LM-D correct responses, LM-I and LM-D-unrelated errors, and LM-I/-D-related errors. The MRI total cerebral brain volume, frontal brain volume, temporal horn volume (THV), and white matter hyperintensities volume (WMHIV) were obtained. Results: Increasing THV (suggesting greater regional atrophy) was associated with lower scores on the LM-correct responses factor. Extensive WMHIV was associated with higher scores on the LM-related errors factor. Conclusion: These results suggest that LM-correct responses could relate to emerging brain alterations. Longitudinal research might enhance the sensitivity of this test to identify preclinical impairment and persons at risk of mild cognitive impairment and dementia.

Original languageEnglish (US)
Pages (from-to)622-628
Number of pages7
JournalAmerican Journal of Alzheimer's Disease and other Dementias
Volume30
Issue number6
DOIs
StatePublished - Sep 13 2015

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Keywords

  • Alzheimer's disease
  • Boston process approach
  • declarative memory
  • Logical Memory
  • preclinical dementia

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology

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