Ventricular volume and dementia progression in the Cardiovascular Health Study

Owen T. Carmichael, Lewis H. Kuller, Oscar L. Lopez, Paul M. Thompson, Rebecca A. Dutton, Allen Lu, Sharon E. Lee, Jessica Y. Lee, Howard J. Aizenstein, Carolyn Cidis Meltzer, Yanxi Liu, Arthur W. Toga, James T. Becker

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Elevated cerebral ventricular volume may be associated with dementia risk and progression. A fully-automated technique that agreed highly with radiological readings was used to estimate lateral ventricle volume on MR scans done at baseline in 1997-99 of 377 subjects in the Cardiovascular Health Study (CHS) from the Pittsburgh Center. 327 subjects were normal or diagnosed with mild cognitive impairment (MCI) at baseline and were evaluated 4 years later. Baseline ventricular volume was analyzed in multivariate models with age, gender, education level, presence and incidence of cerebral infarcts, and dementia category (normal, MCI, or dementia) at baseline and follow-up as fixed effects. Ventricular volume at baseline was significantly higher among subjects normal at baseline and demented 4 years later. Age, gender, education level, and dementia progression were significant factors affecting ventricular volume. Ventricular volume was higher in dementia compared to MCI, higher in MCI compared to controls, and higher in Possible-Alzheimer's-disease (AD) dementia compared to Probable-AD. Larger ventricles in healthy subjects may indicate susceptibility to, or progression of, dementia-related pathology.

Original languageEnglish (US)
Pages (from-to)389-397
Number of pages9
JournalNeurobiology of Aging
Volume28
Issue number3
DOIs
StatePublished - Mar 2007

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Dementia
Health
Alzheimer Disease
Education
Lateral Ventricles
Reading
Healthy Volunteers
Pathology
Cognitive Dysfunction
Incidence

Keywords

  • Automated segmentation
  • Dementia
  • Lateral ventricles
  • Magnetic resonance imaging
  • Mild cognitive impairment

ASJC Scopus subject areas

  • Clinical Neurology
  • Biological Psychiatry
  • Developmental Neuroscience
  • Neurology
  • Psychology(all)

Cite this

Carmichael, O. T., Kuller, L. H., Lopez, O. L., Thompson, P. M., Dutton, R. A., Lu, A., ... Becker, J. T. (2007). Ventricular volume and dementia progression in the Cardiovascular Health Study. Neurobiology of Aging, 28(3), 389-397. https://doi.org/10.1016/j.neurobiolaging.2006.01.006

Ventricular volume and dementia progression in the Cardiovascular Health Study. / Carmichael, Owen T.; Kuller, Lewis H.; Lopez, Oscar L.; Thompson, Paul M.; Dutton, Rebecca A.; Lu, Allen; Lee, Sharon E.; Lee, Jessica Y.; Aizenstein, Howard J.; Meltzer, Carolyn Cidis; Liu, Yanxi; Toga, Arthur W.; Becker, James T.

In: Neurobiology of Aging, Vol. 28, No. 3, 03.2007, p. 389-397.

Research output: Contribution to journalArticle

Carmichael, OT, Kuller, LH, Lopez, OL, Thompson, PM, Dutton, RA, Lu, A, Lee, SE, Lee, JY, Aizenstein, HJ, Meltzer, CC, Liu, Y, Toga, AW & Becker, JT 2007, 'Ventricular volume and dementia progression in the Cardiovascular Health Study', Neurobiology of Aging, vol. 28, no. 3, pp. 389-397. https://doi.org/10.1016/j.neurobiolaging.2006.01.006
Carmichael, Owen T. ; Kuller, Lewis H. ; Lopez, Oscar L. ; Thompson, Paul M. ; Dutton, Rebecca A. ; Lu, Allen ; Lee, Sharon E. ; Lee, Jessica Y. ; Aizenstein, Howard J. ; Meltzer, Carolyn Cidis ; Liu, Yanxi ; Toga, Arthur W. ; Becker, James T. / Ventricular volume and dementia progression in the Cardiovascular Health Study. In: Neurobiology of Aging. 2007 ; Vol. 28, No. 3. pp. 389-397.
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