Venous thrombosis of pancreatic transplants: Diagnosis by duplex sonography

M. C. Foshager, L. J. Hedlund, Christoph Troppmann, E. Benedetti, R. W. Gruessner

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

OBJECTIVE. Our objective was to determine whether elevated pancreatic transplant arterial resistive index (RI) and absence of venous flow correlate with pancreatic transplant venous thrombosis. MATERIALS AND METHODS. Thirteen episodes of surgically documented pancreatic venous thrombosis occurred in 175 pancreases that had been transplanted over a 3-year period. Duplex sonography was performed before surgical exploration in 11 cases. We retrospectively reviewed these 11 sonograms to determine whether blood was flowing in the veins and arteries of the graft. The RI was calculated from all pancreatic artery waveforms. We compared these arterial RIs and the presence or absence of venous flow with those of pancreatic grafts without venous thrombosis to determine sensitivity and specificity. RESULTS. In the venous thrombosis group, thrombosis occurred within 12 days of transplantation (mean, 3.5 days) in all 11 cases. Six cases of thrombosis (55%) occurred within 1 day. Arterial flow was detected within the graft in nine gases (82%) and in the stump of the donor artery between the graft and the recipient iliac artery in the two remaining cases. Antegrade diastolic flow was absent in all arterial tracings. Diastolic flow reversal was present in seven (78%) of nine grafts with detectable intrapancreatic medal flow. Arterial RIs ranged from 1.00 to 2.00 (mean ± SD, 1.27 ± 0.29). Intrapancreatic venous flow was absent in all 11 cases. In the control group (43 examinations in 34 patients) RIs ranged from 0.46 to 1.29 (mean ±SD, 0.72 ± 0.18). Two of 43 arterial tracings had diastolic flow reversal (RI > 1.0). Venous flow was present in all examinations in the control group. A statistically significant difference existed between the RIs in the thrombosis group and the RIs in the control group (p = .0001). CONCLUSION. Reversal of diastolic flow in pancreatic transplant arteries is highly specific for detection of graft venous thrombosis during the first 12 days after transplantation. Our findings suggest that an RI greater than or equal to 1.00 and absence of venous flow, in combination, are highly sensitive and specific for the diagnosis of pancreatic graft venous thrombosis.

Original languageEnglish (US)
Pages (from-to)1269-1273
Number of pages5
JournalAmerican Journal of Roentgenology
Volume169
Issue number5
StatePublished - 1997
Externally publishedYes

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Venous Thrombosis
Ultrasonography
Transplants
Arteries
Thrombosis
Control Groups
Transplantation
Numismatics
Iliac Artery
Pancreas
Veins
Gases
Tissue Donors
Sensitivity and Specificity

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Foshager, M. C., Hedlund, L. J., Troppmann, C., Benedetti, E., & Gruessner, R. W. (1997). Venous thrombosis of pancreatic transplants: Diagnosis by duplex sonography. American Journal of Roentgenology, 169(5), 1269-1273.

Venous thrombosis of pancreatic transplants : Diagnosis by duplex sonography. / Foshager, M. C.; Hedlund, L. J.; Troppmann, Christoph; Benedetti, E.; Gruessner, R. W.

In: American Journal of Roentgenology, Vol. 169, No. 5, 1997, p. 1269-1273.

Research output: Contribution to journalArticle

Foshager, MC, Hedlund, LJ, Troppmann, C, Benedetti, E & Gruessner, RW 1997, 'Venous thrombosis of pancreatic transplants: Diagnosis by duplex sonography', American Journal of Roentgenology, vol. 169, no. 5, pp. 1269-1273.
Foshager, M. C. ; Hedlund, L. J. ; Troppmann, Christoph ; Benedetti, E. ; Gruessner, R. W. / Venous thrombosis of pancreatic transplants : Diagnosis by duplex sonography. In: American Journal of Roentgenology. 1997 ; Vol. 169, No. 5. pp. 1269-1273.
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abstract = "OBJECTIVE. Our objective was to determine whether elevated pancreatic transplant arterial resistive index (RI) and absence of venous flow correlate with pancreatic transplant venous thrombosis. MATERIALS AND METHODS. Thirteen episodes of surgically documented pancreatic venous thrombosis occurred in 175 pancreases that had been transplanted over a 3-year period. Duplex sonography was performed before surgical exploration in 11 cases. We retrospectively reviewed these 11 sonograms to determine whether blood was flowing in the veins and arteries of the graft. The RI was calculated from all pancreatic artery waveforms. We compared these arterial RIs and the presence or absence of venous flow with those of pancreatic grafts without venous thrombosis to determine sensitivity and specificity. RESULTS. In the venous thrombosis group, thrombosis occurred within 12 days of transplantation (mean, 3.5 days) in all 11 cases. Six cases of thrombosis (55{\%}) occurred within 1 day. Arterial flow was detected within the graft in nine gases (82{\%}) and in the stump of the donor artery between the graft and the recipient iliac artery in the two remaining cases. Antegrade diastolic flow was absent in all arterial tracings. Diastolic flow reversal was present in seven (78{\%}) of nine grafts with detectable intrapancreatic medal flow. Arterial RIs ranged from 1.00 to 2.00 (mean ± SD, 1.27 ± 0.29). Intrapancreatic venous flow was absent in all 11 cases. In the control group (43 examinations in 34 patients) RIs ranged from 0.46 to 1.29 (mean ±SD, 0.72 ± 0.18). Two of 43 arterial tracings had diastolic flow reversal (RI > 1.0). Venous flow was present in all examinations in the control group. A statistically significant difference existed between the RIs in the thrombosis group and the RIs in the control group (p = .0001). CONCLUSION. Reversal of diastolic flow in pancreatic transplant arteries is highly specific for detection of graft venous thrombosis during the first 12 days after transplantation. Our findings suggest that an RI greater than or equal to 1.00 and absence of venous flow, in combination, are highly sensitive and specific for the diagnosis of pancreatic graft venous thrombosis.",
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T1 - Venous thrombosis of pancreatic transplants

T2 - Diagnosis by duplex sonography

AU - Foshager, M. C.

AU - Hedlund, L. J.

AU - Troppmann, Christoph

AU - Benedetti, E.

AU - Gruessner, R. W.

PY - 1997

Y1 - 1997

N2 - OBJECTIVE. Our objective was to determine whether elevated pancreatic transplant arterial resistive index (RI) and absence of venous flow correlate with pancreatic transplant venous thrombosis. MATERIALS AND METHODS. Thirteen episodes of surgically documented pancreatic venous thrombosis occurred in 175 pancreases that had been transplanted over a 3-year period. Duplex sonography was performed before surgical exploration in 11 cases. We retrospectively reviewed these 11 sonograms to determine whether blood was flowing in the veins and arteries of the graft. The RI was calculated from all pancreatic artery waveforms. We compared these arterial RIs and the presence or absence of venous flow with those of pancreatic grafts without venous thrombosis to determine sensitivity and specificity. RESULTS. In the venous thrombosis group, thrombosis occurred within 12 days of transplantation (mean, 3.5 days) in all 11 cases. Six cases of thrombosis (55%) occurred within 1 day. Arterial flow was detected within the graft in nine gases (82%) and in the stump of the donor artery between the graft and the recipient iliac artery in the two remaining cases. Antegrade diastolic flow was absent in all arterial tracings. Diastolic flow reversal was present in seven (78%) of nine grafts with detectable intrapancreatic medal flow. Arterial RIs ranged from 1.00 to 2.00 (mean ± SD, 1.27 ± 0.29). Intrapancreatic venous flow was absent in all 11 cases. In the control group (43 examinations in 34 patients) RIs ranged from 0.46 to 1.29 (mean ±SD, 0.72 ± 0.18). Two of 43 arterial tracings had diastolic flow reversal (RI > 1.0). Venous flow was present in all examinations in the control group. A statistically significant difference existed between the RIs in the thrombosis group and the RIs in the control group (p = .0001). CONCLUSION. Reversal of diastolic flow in pancreatic transplant arteries is highly specific for detection of graft venous thrombosis during the first 12 days after transplantation. Our findings suggest that an RI greater than or equal to 1.00 and absence of venous flow, in combination, are highly sensitive and specific for the diagnosis of pancreatic graft venous thrombosis.

AB - OBJECTIVE. Our objective was to determine whether elevated pancreatic transplant arterial resistive index (RI) and absence of venous flow correlate with pancreatic transplant venous thrombosis. MATERIALS AND METHODS. Thirteen episodes of surgically documented pancreatic venous thrombosis occurred in 175 pancreases that had been transplanted over a 3-year period. Duplex sonography was performed before surgical exploration in 11 cases. We retrospectively reviewed these 11 sonograms to determine whether blood was flowing in the veins and arteries of the graft. The RI was calculated from all pancreatic artery waveforms. We compared these arterial RIs and the presence or absence of venous flow with those of pancreatic grafts without venous thrombosis to determine sensitivity and specificity. RESULTS. In the venous thrombosis group, thrombosis occurred within 12 days of transplantation (mean, 3.5 days) in all 11 cases. Six cases of thrombosis (55%) occurred within 1 day. Arterial flow was detected within the graft in nine gases (82%) and in the stump of the donor artery between the graft and the recipient iliac artery in the two remaining cases. Antegrade diastolic flow was absent in all arterial tracings. Diastolic flow reversal was present in seven (78%) of nine grafts with detectable intrapancreatic medal flow. Arterial RIs ranged from 1.00 to 2.00 (mean ± SD, 1.27 ± 0.29). Intrapancreatic venous flow was absent in all 11 cases. In the control group (43 examinations in 34 patients) RIs ranged from 0.46 to 1.29 (mean ±SD, 0.72 ± 0.18). Two of 43 arterial tracings had diastolic flow reversal (RI > 1.0). Venous flow was present in all examinations in the control group. A statistically significant difference existed between the RIs in the thrombosis group and the RIs in the control group (p = .0001). CONCLUSION. Reversal of diastolic flow in pancreatic transplant arteries is highly specific for detection of graft venous thrombosis during the first 12 days after transplantation. Our findings suggest that an RI greater than or equal to 1.00 and absence of venous flow, in combination, are highly sensitive and specific for the diagnosis of pancreatic graft venous thrombosis.

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