Vasopressor use in the critical care unit for treatment of persistent post-carotid artery stent induced hypotension

Mohan Reddi Nandalur, Howard Cooper, Lowell F. Satler, Kiran R. Nandalur, John R. Laird

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Introduction: Hypotension is common following carotid artery stenting (CAS), and may be mediated by vagal stimulation and/or suppression of spinal sympathetic outflow. Both mixed α/Β agonists (dopamine (DA)), and more selective α- agonists (norepinephrine (NE) and phenylephrine (PE)), have been used, but the most effective treatment of post-CAS hypotension is unknown. Materials and methods: We analyzed data for consecutive patients requiring vasopressor treatment of post-CAS hypotension. The treating physician made choice of vasopressor. Endpoints included infusion duration, coronary care unit (CCU) length of stay (LOS), and any major adverse events (death, stroke, myocardial infarction, arrhythmia). Results: During the study period, CAS stenting was performed in 623 patients. CCU admission in atropine non-responders for vasopressor treatment was required in 42 patients (6.7%). DA was used in 20 patients (48%), NE in 13 patients (31%), and PE in nine patients (21%). Vasopressor infusion time was 31.8 ± 10.6 h for DA, compared with 23.8 ± 8.1 h for NE (P ≤ 0.052) and 22.1 ± 6.1 h (P ≤ 0.028) for PE. CCU LOS was 46.5 ± 14.1 h for DA compared with 36.9 ± 9.1 h for the NE and PE groups combined (P ≤ 0.056). Major adverse events were more common in patients receiving DA than among patients receiving NE or PE (P ≤ 0.04). Conclusions: Compared with DA, treatment of post-CAS hypotension with a selective α-agonist (NE or PE) is associated with shorter drug infusion time, shorter CCU LOS, and fewer major adverse events.

Original languageEnglish (US)
Pages (from-to)232-237
Number of pages6
JournalNeurocritical Care
Volume7
Issue number3
DOIs
StatePublished - Dec 2007
Externally publishedYes

Keywords

  • Complication
  • Peripheral vascular intervention
  • Vasopressor

ASJC Scopus subject areas

  • Clinical Neurology
  • Critical Care and Intensive Care Medicine

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