Vasomotor symptoms and lipid profiles in women transitioning through menopause

Rebecca C. Thurston, Samar R. El Khoudary, Kim Sutton-Tyrrell, Carolyn J. Crandall, Ellen B Gold, Barbara Sternfeld, Hadine Joffe, Faith Selzer, Karen A. Matthews

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

OBJECTIVE: To examine associations between vasomotor symptoms and lipids over 8 years, controlling for other cardiovascular risk factors, estradiol, and follicle-stimulating hormone. METHODS: Study of Women's Health Across the Nation participants (N=3,201), aged 42-52 years at entry, completed interviews on frequency of hot flushes and night sweats (none, 1-5 days, 6 days or more, in the past 2 weeks) physical measures (blood pressure, height, weight), and blood draws (low-density lipoprotein [LDL], high-density lipoprotein [HDL], apolipoprotein A-1, apolipoprotein B, lipoprotein[a], triglycerides, serum estradiol, follicle-stimulating hormone) yearly for 8 years. Relations between symptoms and lipids were examined in linear mixed models adjusting for cardiovascular risk factors, medications, and hormones. RESULTS: Compared with no flushes, experiencing hot flushes was associated with significantly higher LDL (1-5 days: β [standard error]=1.48 [0.47], P<.01; 6 days or more: β [standard error]=2.13 [0.62], P<.001), HDL (1-5 days: β [standard error]=0.30 [0.18]; 6 days or more: β [standard error]=0.77 [0.24], P<.01), apolipoprotein A-1 (1-5 days: β [standard error]=0.92 [0.47], P<.10; 6 days or more: β [standard error]=1.97 [0.62], P<.01), apolipoprotein B (1-5 days: β [standard error]=1.41 [0.41], P<.001; 6 days or more: β [standard error]=2.51 [0.54], P<.001), and triglycerides (1-5 days: percent change [95% confidence interval]=2.91 [1.41-4.43], P<.001; 6 days or more: percent change [95% confidence interval[=5.90 [3.86-7.97], P<.001) in multivariable models. Findings largely persisted adjusting for hormones. Estimated mean differences in lipid levels between hot flushes 6 days or more compared with no days ranged from less than 1 (for HDL) to 10 mg/dL (for triglycerides). Night sweats were similar. Associations were strongest for lean women. CONCLUSION: Vasomotor symptoms were associated with higher LDL, HDL, apolipoprotein A-1, apolipoprotein B, and triglycerides. Lipids should be considered in links between hot flushes and cardiovascular risk. LEVEL OF EVIDENCE: II.

Original languageEnglish (US)
Pages (from-to)753-761
Number of pages9
JournalObstetrics and Gynecology
Volume119
Issue number4
DOIs
StatePublished - Apr 2012

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Menopause
Apolipoprotein A-I
Apolipoproteins B
Triglycerides
HDL Lipoproteins
LDL Lipoproteins
Lipids
Sweat
Follicle Stimulating Hormone
Estradiol
Hormones
Confidence Intervals
Women's Health
Lipoproteins
Linear Models
Interviews
Blood Pressure
Weights and Measures
Serum
high density lipoprotein-1

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Thurston, R. C., El Khoudary, S. R., Sutton-Tyrrell, K., Crandall, C. J., Gold, E. B., Sternfeld, B., ... Matthews, K. A. (2012). Vasomotor symptoms and lipid profiles in women transitioning through menopause. Obstetrics and Gynecology, 119(4), 753-761. https://doi.org/10.1097/AOG.0b013e31824a09ec

Vasomotor symptoms and lipid profiles in women transitioning through menopause. / Thurston, Rebecca C.; El Khoudary, Samar R.; Sutton-Tyrrell, Kim; Crandall, Carolyn J.; Gold, Ellen B; Sternfeld, Barbara; Joffe, Hadine; Selzer, Faith; Matthews, Karen A.

In: Obstetrics and Gynecology, Vol. 119, No. 4, 04.2012, p. 753-761.

Research output: Contribution to journalArticle

Thurston, RC, El Khoudary, SR, Sutton-Tyrrell, K, Crandall, CJ, Gold, EB, Sternfeld, B, Joffe, H, Selzer, F & Matthews, KA 2012, 'Vasomotor symptoms and lipid profiles in women transitioning through menopause', Obstetrics and Gynecology, vol. 119, no. 4, pp. 753-761. https://doi.org/10.1097/AOG.0b013e31824a09ec
Thurston RC, El Khoudary SR, Sutton-Tyrrell K, Crandall CJ, Gold EB, Sternfeld B et al. Vasomotor symptoms and lipid profiles in women transitioning through menopause. Obstetrics and Gynecology. 2012 Apr;119(4):753-761. https://doi.org/10.1097/AOG.0b013e31824a09ec
Thurston, Rebecca C. ; El Khoudary, Samar R. ; Sutton-Tyrrell, Kim ; Crandall, Carolyn J. ; Gold, Ellen B ; Sternfeld, Barbara ; Joffe, Hadine ; Selzer, Faith ; Matthews, Karen A. / Vasomotor symptoms and lipid profiles in women transitioning through menopause. In: Obstetrics and Gynecology. 2012 ; Vol. 119, No. 4. pp. 753-761.
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abstract = "OBJECTIVE: To examine associations between vasomotor symptoms and lipids over 8 years, controlling for other cardiovascular risk factors, estradiol, and follicle-stimulating hormone. METHODS: Study of Women's Health Across the Nation participants (N=3,201), aged 42-52 years at entry, completed interviews on frequency of hot flushes and night sweats (none, 1-5 days, 6 days or more, in the past 2 weeks) physical measures (blood pressure, height, weight), and blood draws (low-density lipoprotein [LDL], high-density lipoprotein [HDL], apolipoprotein A-1, apolipoprotein B, lipoprotein[a], triglycerides, serum estradiol, follicle-stimulating hormone) yearly for 8 years. Relations between symptoms and lipids were examined in linear mixed models adjusting for cardiovascular risk factors, medications, and hormones. RESULTS: Compared with no flushes, experiencing hot flushes was associated with significantly higher LDL (1-5 days: β [standard error]=1.48 [0.47], P<.01; 6 days or more: β [standard error]=2.13 [0.62], P<.001), HDL (1-5 days: β [standard error]=0.30 [0.18]; 6 days or more: β [standard error]=0.77 [0.24], P<.01), apolipoprotein A-1 (1-5 days: β [standard error]=0.92 [0.47], P<.10; 6 days or more: β [standard error]=1.97 [0.62], P<.01), apolipoprotein B (1-5 days: β [standard error]=1.41 [0.41], P<.001; 6 days or more: β [standard error]=2.51 [0.54], P<.001), and triglycerides (1-5 days: percent change [95{\%} confidence interval]=2.91 [1.41-4.43], P<.001; 6 days or more: percent change [95{\%} confidence interval[=5.90 [3.86-7.97], P<.001) in multivariable models. Findings largely persisted adjusting for hormones. Estimated mean differences in lipid levels between hot flushes 6 days or more compared with no days ranged from less than 1 (for HDL) to 10 mg/dL (for triglycerides). Night sweats were similar. Associations were strongest for lean women. CONCLUSION: Vasomotor symptoms were associated with higher LDL, HDL, apolipoprotein A-1, apolipoprotein B, and triglycerides. Lipids should be considered in links between hot flushes and cardiovascular risk. LEVEL OF EVIDENCE: II.",
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N2 - OBJECTIVE: To examine associations between vasomotor symptoms and lipids over 8 years, controlling for other cardiovascular risk factors, estradiol, and follicle-stimulating hormone. METHODS: Study of Women's Health Across the Nation participants (N=3,201), aged 42-52 years at entry, completed interviews on frequency of hot flushes and night sweats (none, 1-5 days, 6 days or more, in the past 2 weeks) physical measures (blood pressure, height, weight), and blood draws (low-density lipoprotein [LDL], high-density lipoprotein [HDL], apolipoprotein A-1, apolipoprotein B, lipoprotein[a], triglycerides, serum estradiol, follicle-stimulating hormone) yearly for 8 years. Relations between symptoms and lipids were examined in linear mixed models adjusting for cardiovascular risk factors, medications, and hormones. RESULTS: Compared with no flushes, experiencing hot flushes was associated with significantly higher LDL (1-5 days: β [standard error]=1.48 [0.47], P<.01; 6 days or more: β [standard error]=2.13 [0.62], P<.001), HDL (1-5 days: β [standard error]=0.30 [0.18]; 6 days or more: β [standard error]=0.77 [0.24], P<.01), apolipoprotein A-1 (1-5 days: β [standard error]=0.92 [0.47], P<.10; 6 days or more: β [standard error]=1.97 [0.62], P<.01), apolipoprotein B (1-5 days: β [standard error]=1.41 [0.41], P<.001; 6 days or more: β [standard error]=2.51 [0.54], P<.001), and triglycerides (1-5 days: percent change [95% confidence interval]=2.91 [1.41-4.43], P<.001; 6 days or more: percent change [95% confidence interval[=5.90 [3.86-7.97], P<.001) in multivariable models. Findings largely persisted adjusting for hormones. Estimated mean differences in lipid levels between hot flushes 6 days or more compared with no days ranged from less than 1 (for HDL) to 10 mg/dL (for triglycerides). Night sweats were similar. Associations were strongest for lean women. CONCLUSION: Vasomotor symptoms were associated with higher LDL, HDL, apolipoprotein A-1, apolipoprotein B, and triglycerides. Lipids should be considered in links between hot flushes and cardiovascular risk. LEVEL OF EVIDENCE: II.

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