James S W Prutton, Nicola Pusterla

Research output: Chapter in Book/Report/Conference proceedingChapter


This chapter discusses the clinical signs, immunologic mechanisms and etiologic associations, diagnostics, treatment of vasculitis in horses. The apparent indiscriminate nature of vasculitis can lead either to a localized disease (one organ, most frequently cutaneous disease) or to a multisystemic disease, with the risk of renal failure. The specific diseases covered include localized thrombophlebitis, pastern and cannon leukocytoclastic vasculitis (PCLV), drug-induced vasculitis, photo-activated vasculitis, equine granulocytic anaplasmosis, equine viral arteritis (EVA), equine herpevirus-1 (EHV-1), and African horse sickness. PCLV can often be associated with long-standing dermatophytosis, bacterial infection or chorioptic mange. Biopsy is critical to the diagnosis of this disease, with: histopathological evidence deep dermal and hypodermal foci of hemorrhage; moderate edema of the dermis; and neutrophil infiltration surrounding the vessels. The diagnosis of a drug-induced vasculitis is based on the temporal relationship between the clinical manifestation of vasculitis and the use of the offending drug.

Original languageEnglish (US)
Title of host publicationEquine Clinical Immunology
Number of pages10
ISBN (Electronic)9781119086512
ISBN (Print)9781118558874
StatePublished - Jan 5 2016


  • African horse sickness
  • African horse sickness
  • Drug-induced vasculitis
  • EHV-1
  • Equine granulocytic anaplasmosis
  • EVA
  • Localized thrombophlebitis
  • PCLV
  • Photo-activated vasculitis

ASJC Scopus subject areas

  • veterinary(all)


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