Vascularizing engineered tissues for in vivo and in vitro applications

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

Engineering human tissues to enhance, replace or simulate physiological function has enormous potential to significantly impact human healthcare. A fundamental feature of human tissue is a vascular supply. The creation of a living dynamic circulation has proved to be a significant challenge. The past decade has brought several new approaches to create a vascular supply for three-dimensional human tissues for both in vitro and in vivo applications. However, future challenges remain, and new innovation in the areas of cell sourcing, the extracellular matrix, and controlling the immune response will be required to fully harness the potential of tissue engineering.

Original languageEnglish (US)
Title of host publicationCardiac Regeneration and Repair
Subtitle of host publicationBiomaterials and Tissue Engineering
PublisherElsevier Ltd.
Pages283-298
Number of pages16
ISBN (Print)9780857096593
DOIs
StatePublished - Jan 1 2014

Keywords

  • Blood supply
  • Microcirculation
  • Regenerative medicine

ASJC Scopus subject areas

  • Dentistry(all)
  • Medicine(all)

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  • Cite this

    George, S. (2014). Vascularizing engineered tissues for in vivo and in vitro applications. In Cardiac Regeneration and Repair: Biomaterials and Tissue Engineering (pp. 283-298). Elsevier Ltd.. https://doi.org/10.1533/9780857096715.2.283