Vascularized bone marrow transplantation: Pathology of composite tissue transplantation-induced graft-versus-host-disease

Rajen Ramsamooj, Charles W. Hewitt

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Composite tissue allografts (CTAs) represent the transplantation of several tissue types including integumentary, musculoskeletal, cutaneous, and hematopoietic elements. The rat hindlimb CTA using a parental limb to an F1 hybrid host actually represents a vascularized bone marrow transplant model. The hindlimb CTA provides transplantation of precursor hematolymphoid (bone marrow) and mature (blood and lymph nodes) elements by a surgical approach along with transfer of their syngeneic/supportive microenvironments. Immediate engraftment with and without immune modulation has been previously shown.

Original languageEnglish (US)
Title of host publicationTransplantation of Composite Tissue Allografts
PublisherSpringer US
Pages272-277
Number of pages6
ISBN (Print)9780387746821, 9780387746814
DOIs
StatePublished - 2008

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

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    Ramsamooj, R., & Hewitt, C. W. (2008). Vascularized bone marrow transplantation: Pathology of composite tissue transplantation-induced graft-versus-host-disease. In Transplantation of Composite Tissue Allografts (pp. 272-277). Springer US. https://doi.org/10.1007/978-0-387-74682-1_19