Vascular risk at younger ages most strongly associates with current and future brain volume

Matthew P. Pase, Kendra Davis-Plourde, Jayandra J. Himali, Claudia L. Satizabal, Hugo Aparicio, Sudha Seshadri, Alexa S. Beiser, Charles DeCarli

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

OBJECTIVE: Given the potential therapeutic effect of vascular disease control timing to reduce dementia risk, we investigated the age-related influences of vascular risk factor burden on brain structure throughout the lifespan.

METHODS: We studied participants from the community-based prospective Framingham Heart Study. Overall vascular risk factor burden was calculated according to the Framingham Stroke Risk Profile, a validated algorithm that predicts stroke risk. Brain volume was estimated by MRI. We used cross-sectional data to examine how the strength of association between vascular risk factor burden and brain volume changed across each age decade from age 45-54 years through to 85-94 years (N = 2,887). Second, we leveraged up to 40 years of longitudinal data to determine how the strength of association between vascular risk factor burden and brain volume changed when vascular risk factors were examined at progressively earlier ages (N = 7,868).

RESULTS: In both cross-sectional and longitudinal analyses, higher vascular risk factor burden was associated with lower brain volume across each age decade. In the cross-sectional analysis, the strength of this association decreased with each decade of advancing age (p for trend < 0.0001). In longitudinal analysis, the strength of association between vascular risk factor burden and brain volume was stronger when vascular risk factors were measured at younger ages. For example, vascular risk factor burden was most strongly associated with lower brain volume in later life when vascular risk factors were measured at age 45 years.

CONCLUSION: Vascular risk factors at younger ages appear to have detrimental effects on current and future brain volume.

Original languageEnglish (US)
Pages (from-to)e1479-e1486
JournalNeurology
Volume91
Issue number16
DOIs
StatePublished - Oct 16 2018

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Blood Vessels
Brain
vascular factor
Cross-Sectional Studies
Stroke
Therapeutic Uses
Vascular Diseases
Dementia

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Pase, M. P., Davis-Plourde, K., Himali, J. J., Satizabal, C. L., Aparicio, H., Seshadri, S., ... DeCarli, C. (2018). Vascular risk at younger ages most strongly associates with current and future brain volume. Neurology, 91(16), e1479-e1486. https://doi.org/10.1212/WNL.0000000000006360

Vascular risk at younger ages most strongly associates with current and future brain volume. / Pase, Matthew P.; Davis-Plourde, Kendra; Himali, Jayandra J.; Satizabal, Claudia L.; Aparicio, Hugo; Seshadri, Sudha; Beiser, Alexa S.; DeCarli, Charles.

In: Neurology, Vol. 91, No. 16, 16.10.2018, p. e1479-e1486.

Research output: Contribution to journalArticle

Pase, MP, Davis-Plourde, K, Himali, JJ, Satizabal, CL, Aparicio, H, Seshadri, S, Beiser, AS & DeCarli, C 2018, 'Vascular risk at younger ages most strongly associates with current and future brain volume', Neurology, vol. 91, no. 16, pp. e1479-e1486. https://doi.org/10.1212/WNL.0000000000006360
Pase MP, Davis-Plourde K, Himali JJ, Satizabal CL, Aparicio H, Seshadri S et al. Vascular risk at younger ages most strongly associates with current and future brain volume. Neurology. 2018 Oct 16;91(16):e1479-e1486. https://doi.org/10.1212/WNL.0000000000006360
Pase, Matthew P. ; Davis-Plourde, Kendra ; Himali, Jayandra J. ; Satizabal, Claudia L. ; Aparicio, Hugo ; Seshadri, Sudha ; Beiser, Alexa S. ; DeCarli, Charles. / Vascular risk at younger ages most strongly associates with current and future brain volume. In: Neurology. 2018 ; Vol. 91, No. 16. pp. e1479-e1486.
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